{"id":"W4221009737","doi":"10.1038/s41467-022-29244-1","title":"UBR4/POE facilitates secretory trafficking to maintain circadian clock synchrony","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Celiac Association; McGill University; Ted Rogers Centre for Heart Research; Hatch (Canada); University of Toronto","funders":"Japan Society for the Promotion of Science; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Circadian clock; Circadian rhythm; Cell biology; Biology; Biological clock; Computer science; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002737282,0.0003162783,0.0003105599,0.0002819308,0.0001856347,0.0004477949,0.0003759375,0.0004274444,0.001830616],"category_scores_gemma":[0.0002005327,0.000184297,0.0002876675,0.0001133239,0.0003955473,0.0004440065,0.0005944759,0.0005227046,0.0006502111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003564862,"about_ca_system_score_gemma":0.0002418219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002849743,"about_ca_topic_score_gemma":0.0004028551,"domain_scores_codex":[0.9998436,0.00002169412,0.00001603123,0.00004082182,0.00003262054,0.00004516431],"domain_scores_gemma":[0.9998312,0.0000134102,0.00005675829,0.00003421607,0.00002005649,0.00004438314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009233271,0.00001817315,0.0003310768,0.00002882306,0.000006179555,0.00006678345,0.000006678616,0.0001061182,0.9975488,0.0003307322,0.00005301402,0.001411355],"study_design_scores_gemma":[0.00002765406,0.0001076996,0.007078361,0.000006280371,0.00001614238,0.00042734,0.0000352408,0.002235809,0.9852961,0.0001882861,0.004574236,0.000006924714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901934,0.001014026,0.005907912,0.0002375733,0.00004063349,0.00001419793,0.0002003779,0.0002326494,0.002159221],"genre_scores_gemma":[0.9926609,0.000397144,0.002735777,0.00006238092,0.00000894741,0.00001280508,0.0001982881,0.00005472768,0.003868908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001830616,"threshold_uncertainty_score":0.00612402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02915390357027046,"score_gpt":0.2904449961282819,"score_spread":0.2612910925580114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}