{"id":"W4221011693","doi":"10.1038/s41401-022-00868-9","title":"Platelet CFTR inhibition enhances arterial thrombosis via increasing intracellular Cl− concentration and activation of SGK1 signaling pathway","year":2022,"lang":"en","type":"article","venue":"Acta Pharmacologica Sinica","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Guangzhou Municipal Science and Technology Project; Zhengzhou University; University of Toronto; Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"Platelet; SGK1; Platelet activation; Cystic fibrosis transmembrane conductance regulator; Chemistry; Endocrinology; Internal medicine; Phosphorylation; Medicine; Cystic fibrosis; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002161276,0.0003213838,0.0004008898,0.0001978712,0.0002246709,0.0004996415,0.0001907863,0.0005400986,0.002417145],"category_scores_gemma":[0.0003140817,0.0001902485,0.0005225891,0.0001302568,0.0003340142,0.0003482455,0.000222771,0.001548058,0.0004188278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003307614,"about_ca_system_score_gemma":0.0004962121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006559051,"about_ca_topic_score_gemma":0.0009404119,"domain_scores_codex":[0.9997901,0.00004442439,0.00001886796,0.00003124796,0.0000423685,0.0000730548],"domain_scores_gemma":[0.9998957,0.00002067646,0.00003421926,0.00001019971,0.00001260643,0.00002663261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006344779,0.0005990678,0.001231742,0.0004456341,0.0001212908,0.0005539771,0.00006679352,0.0002825769,0.9747651,0.0008412737,0.001960329,0.01278738],"study_design_scores_gemma":[0.002004514,0.006867534,0.03012175,0.00008340766,0.0005235359,0.001574798,0.0002580354,0.004568601,0.9381016,0.0008366831,0.01501617,0.00004323614],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819977,0.00903448,0.002383875,0.001644733,0.000403779,0.0000840952,0.0004781925,0.0002925996,0.00368057],"genre_scores_gemma":[0.9941626,0.002772114,0.0007873748,0.0003679845,0.00007610072,0.00006689772,0.0002871436,0.00001291965,0.001466883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002417145,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0314021921901132,"score_gpt":0.3230075276188494,"score_spread":0.2916053354287362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}