{"id":"W4221015144","doi":"10.1101/2022.01.25.477724","title":"Distinct genetic determinants and mechanisms of SARS-CoV-2 resistance to remdesivir","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Centers for Disease Control and Prevention; National Institutes of Health; Ministero dello Sviluppo Economico; National Institute of Allergy and Infectious Diseases; Vanderbilt University Medical Center","keywords":"Biology; Nucleoside; Virology; Genetics; Lineage (genetic); RNA-dependent RNA polymerase; Viral replication; Nucleotide; RNA; Virus; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001557762,0.0002107194,0.0001824713,0.0002563031,0.0001121365,0.0003217492,0.00016827,0.0002843303,0.0008612568],"category_scores_gemma":[0.000198181,0.000146809,0.0003282373,0.00009074933,0.0001565041,0.000182764,0.0001982619,0.000374846,0.0002874849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002737295,"about_ca_system_score_gemma":0.0001068383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004992763,"about_ca_topic_score_gemma":0.0004557154,"domain_scores_codex":[0.9998678,0.00002537711,0.00001150178,0.00001798685,0.00003946022,0.00003795771],"domain_scores_gemma":[0.9998708,0.00002817063,0.00003488831,0.00001466117,0.00002578142,0.00002575237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008434794,0.00002596909,0.001366795,0.000008890274,0.000005052996,0.00005467446,0.00001993943,0.00008498979,0.9974567,0.00007328604,0.00001343271,0.0008060316],"study_design_scores_gemma":[0.00005956219,0.001508499,0.1550546,0.00001852892,0.0000467451,0.001842669,0.0002378877,0.004081086,0.8350018,0.0002336624,0.001896707,0.00001837866],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987055,0.0002435645,0.0003909385,0.00001543721,0.000002113854,0.00001448348,0.00009303402,0.000009379413,0.0005255066],"genre_scores_gemma":[0.9988421,0.00009991963,0.0003207895,0.00001946139,0.000003366879,0.00001195233,0.0002702859,0.000003691088,0.000428494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008612568,"threshold_uncertainty_score":0.002881169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03572574583815228,"score_gpt":0.304042160704724,"score_spread":0.2683164148665717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}