{"id":"W4221018380","doi":"10.1038/s41586-022-04661-w","title":"A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic","year":2022,"lang":"en","type":"article","venue":"Nature","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":232,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; Université de Sherbrooke; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Faculty of Medicine, University of British Columbia; National Institutes of Health; University of British Columbia; Genome British Columbia; Northeast Ohio Medical University; Johns Hopkins University; Université de Sherbrooke; Canadian Institutes of Health Research; National Institute of Biomedical Imaging and Bioengineering; Mitacs; National Institute of General Medical Sciences; George Mason University","keywords":"Proteases; TMPRSS2; Virus; Transmembrane protein; Serine protease; Virology; Biology; Coronavirus disease 2019 (COVID-19); Chemistry; Protease; Medicine; Enzyme; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0002980805,0.0001934652,0.000269197,0.0002087006,0.000224739,0.00005224776,0.0001788002,0.0004779612,0.00002251768],"category_scores_gemma":[0.0002100462,0.0001560093,0.00009217719,0.0005485377,0.00008416259,0.00006957972,0.0002080503,0.003775772,0.00006723787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001720485,"about_ca_system_score_gemma":0.0004601963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000574538,"about_ca_topic_score_gemma":0.00001380964,"domain_scores_codex":[0.9980747,0.0001101657,0.0001587406,0.0004271016,0.0008340834,0.0003952052],"domain_scores_gemma":[0.9993177,0.0001071985,0.0000553577,0.0003810547,0.0001058934,0.0000328187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001176032,0.0003136735,0.003100669,0.0002157016,0.00009839259,0.0005657023,0.0008049919,4.114433e-8,0.9772618,0.0006037887,0.001660682,0.0141985],"study_design_scores_gemma":[0.002174031,0.001109966,0.002266817,0.00003071197,0.00007630784,0.0004868029,0.0002978252,0.00008151211,0.4538994,0.0009510875,0.5384115,0.0002140169],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833987,0.007348997,0.000001346446,0.003827141,0.0002835326,0.0007098212,0.000008822292,0.0001020711,0.004319589],"genre_scores_gemma":[0.8563491,0.000004718296,0.00003305331,0.142995,0.0002519118,0.0001154224,0.000003235671,0.00003751654,0.0002100208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5367508,"threshold_uncertainty_score":0.9985226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0306789101958191,"score_gpt":0.3548357392640786,"score_spread":0.3241568290682595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}