{"id":"W4221018380","doi":"10.1038/s41586-022-04661-w","title":"A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic","year":2022,"lang":"en","type":"article","venue":"Nature","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":232,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; Université de Sherbrooke; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Faculty of Medicine, University of British Columbia; National Institutes of Health; University of British Columbia; Genome British Columbia; Northeast Ohio Medical University; Johns Hopkins University; Université de Sherbrooke; Canadian Institutes of Health Research; National Institute of Biomedical Imaging and Bioengineering; Mitacs; National Institute of General Medical Sciences; George Mason University","keywords":"Proteases; TMPRSS2; Virus; Transmembrane protein; Serine protease; Virology; Biology; Coronavirus disease 2019 (COVID-19); Chemistry; Protease; Medicine; Enzyme; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000885814,0.0003064426,0.0002608926,0.000171576,0.00008746354,0.000190094,0.0001669142,0.0002557125,0.001421388],"category_scores_gemma":[0.00004705086,0.00008260832,0.0002022428,0.0001327277,0.0001077528,0.0001169193,0.00009920313,0.000489494,0.0003344692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001213038,"about_ca_system_score_gemma":0.0001441433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002774283,"about_ca_topic_score_gemma":0.0006134444,"domain_scores_codex":[0.9999514,0.000007111719,0.000003790964,0.000008382091,0.00001355789,0.00001574185],"domain_scores_gemma":[0.9999709,0.000004621696,0.00000730206,0.000003663127,0.000003411825,0.00001010703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005226302,0.0002487256,0.0002408729,0.00007954539,0.00001228662,0.00006769316,0.00000834293,0.0002156485,0.988059,0.00009781171,0.0002609173,0.01018655],"study_design_scores_gemma":[0.0003027753,0.006520979,0.008756387,0.00001388149,0.00005229914,0.0008311195,0.0000203592,0.002014366,0.9727589,0.00006357667,0.008654965,0.00001031052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866067,0.005688408,0.001987403,0.0001509037,0.00006377682,0.00009946319,0.0004333041,0.000175958,0.004794098],"genre_scores_gemma":[0.9944823,0.00188773,0.00132119,0.00009267365,0.00002533479,0.00002834971,0.000394576,0.000008007132,0.001759758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001421388,"threshold_uncertainty_score":0.00475502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0306789101958191,"score_gpt":0.3548357392640786,"score_spread":0.3241568290682595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}