{"id":"W4221019027","doi":"10.1007/s12325-022-02104-6","title":"Impact of Infliximab-dyyb (Infliximab Biosimilar) on Clinical and Patient-Reported Outcomes: 1-Year Follow-up Results from an Observational Real-World Study Among Patients with Inflammatory Bowel Disease in the US and Canada (the ONWARD Study)","year":2022,"lang":"en","type":"article","venue":"Advances in Therapy","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Pfizer","keywords":"Infliximab; Medicine; Biosimilar; Inflammatory bowel disease; Internal medicine; Ulcerative colitis; Observational study; Adverse effect; Disease","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002041032,0.0003306744,0.0005556459,0.0006960124,0.0008181816,0.001103821,0.000709803,0.0005580396,0.0008129412],"category_scores_gemma":[0.003677289,0.0002423322,0.0008669656,0.001606881,0.0005845086,0.0004372527,0.0007225451,0.0006496221,0.0001689396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002924433,"about_ca_system_score_gemma":0.002920916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.2785379,"about_ca_topic_score_gemma":0.3090643,"domain_scores_codex":[0.9980862,0.0005128484,0.0001992375,0.0003433695,0.0005418435,0.0003165058],"domain_scores_gemma":[0.9949344,0.0005766021,0.002355937,0.0002977512,0.001045853,0.0007894614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004550141,0.00007151611,0.9983761,0.0000128749,0.0001449639,0.00002290137,0.00009879629,0.00003337867,0.00005520301,0.000006447226,0.00007695496,0.0006457506],"study_design_scores_gemma":[0.00003837153,0.0001561036,0.9993528,0.000006702745,0.00005558825,0.00003581057,0.0001377977,0.00007904285,0.00002377601,0.000003444501,0.0001064246,0.000004255237],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985995,0.0002712427,0.00002870226,0.00002656008,0.000003139957,0.00002651046,0.0008434923,0.000001427235,0.0001994558],"genre_scores_gemma":[0.9981762,0.0001549331,0.00006334074,0.00003617175,0.000005695265,0.0000220462,0.001447477,0.000001099743,0.0000929785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2785379,"threshold_uncertainty_score":0.5538332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03858910153886844,"score_gpt":0.3536401462139039,"score_spread":0.3150510446750355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}