{"id":"W4221024040","doi":"10.1039/d2ob00016d","title":"Structure-activity relationship and bioactivity studies of neurotrophic <i>trans</i> -banglene","year":2022,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canada Foundation for Innovation; Canada Research Coordinating Committee","keywords":"Chemistry; Long-term potentiation; Neurotrophin; Neurotrophic factors; Enantiomer; Brain-derived neurotrophic factor; Structure–activity relationship; In vitro; Protein kinase B; Biochemistry; Neuroscience; Cell biology; Signal transduction; Pharmacology; Receptor; Stereochemistry; Psychology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001988454,0.0002726832,0.0001576114,0.000186508,0.0002034052,0.0002168616,0.0002370444,0.0001766526,0.001870892],"category_scores_gemma":[0.0002206263,0.00009411645,0.0001627539,0.0002195984,0.0001819024,0.0002337138,0.0001404326,0.0003768877,0.0003837237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002498907,"about_ca_system_score_gemma":0.0002424084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001570872,"about_ca_topic_score_gemma":0.002386579,"domain_scores_codex":[0.9999052,0.00001658812,0.000009310452,0.0000160354,0.00002273175,0.0000301058],"domain_scores_gemma":[0.9998666,0.00003013399,0.00002606209,0.00001013081,0.00003483524,0.00003223614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001980999,0.00006527447,0.0001371353,0.0001388241,0.000006083458,0.00007999434,0.00004021593,0.0003255673,0.9948066,0.0004547019,0.00005506526,0.003692513],"study_design_scores_gemma":[0.00001014979,0.001319689,0.0009181856,0.00001075389,0.00001210969,0.0001942558,0.0000324561,0.0002997078,0.9942173,0.0000724804,0.002903876,0.000009067444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751095,0.005909049,0.00341714,0.0000830695,0.00003349912,0.00008875559,0.0005813516,0.00003424555,0.01474338],"genre_scores_gemma":[0.987915,0.004230584,0.002338455,0.00003822207,0.000008753805,0.00002173371,0.0006730527,0.00001079628,0.004763333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001870892,"threshold_uncertainty_score":0.006258786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03297824657758854,"score_gpt":0.2700479134079324,"score_spread":0.2370696668303439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}