{"id":"W4221026952","doi":"10.1002/alz.12651","title":"Results and insights from a phase I clinical trial of Lomecel‐B for Alzheimer's disease","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"","keywords":"Clinical endpoint; Placebo; Medicine; Clinical trial; Disease; Biomarker; Neurocognitive; Oncology; Randomized controlled trial; Internal medicine; Cognition; Pathology; Psychiatry; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00710263,0.001083403,0.0008921284,0.0001951201,0.0002426029,0.0006323662,0.0006108292,0.0009900423,0.005008782],"category_scores_gemma":[0.002442232,0.0002148347,0.0009154266,0.000182884,0.0007167776,0.0005344266,0.000257052,0.001793175,0.0009705362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003451545,"about_ca_system_score_gemma":0.001435773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001461462,"about_ca_topic_score_gemma":0.0002970151,"domain_scores_codex":[0.9988575,0.0006837309,0.00008996478,0.000113013,0.0001449209,0.0001108672],"domain_scores_gemma":[0.9984636,0.0005905484,0.0003959668,0.0001287493,0.0001328182,0.0002882105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5439038,0.04481556,0.01790218,0.004440432,0.00229702,0.0007782406,0.0005153957,0.006455546,0.163784,0.003092607,0.009204682,0.2028106],"study_design_scores_gemma":[0.2332948,0.6809074,0.02195076,0.0002110456,0.003149164,0.0007356114,0.0001017627,0.002054247,0.04162287,0.002927574,0.01297818,0.00006657484],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.941526,0.009336271,0.01133478,0.003894562,0.00036351,0.01150793,0.007745841,0.0002132525,0.01407788],"genre_scores_gemma":[0.9772807,0.002501422,0.00508057,0.002947184,0.0002794547,0.004893668,0.003827847,0.00002450274,0.003164587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00710263,"threshold_uncertainty_score":0.03756273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09775171992140821,"score_gpt":0.4008519244168428,"score_spread":0.3031002044954346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}