{"id":"W4221027434","doi":"10.1186/s13075-022-02745-6","title":"Longitudinal assessment of reactivity and affinity profile of anti-Jo1 autoantibodies to distinct HisRS domains and a splice variant in a cohort of patients with myositis and anti-synthetase syndrome","year":2022,"lang":"en","type":"article","venue":"Arthritis Research & Therapy","topic":"Inflammatory Myopathies and Dermatomyositis","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium","funders":"Reumatikerförbundet; Vetenskapsrådet; Stockholms Läns Landsting; European Federation of Pharmaceutical Industries and Associations; Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse; Ulla och Gustaf af Ugglas Stiftelse; Stiftelsen Konung Gustaf V:s 80-årsfond; Karolinska Institutet; European Commission; Bristol-Myers Squibb; Association Française contre les Myopathies; Myositis Association; Hjärt-Lungfonden; McGill University","keywords":"Autoantibody; Medicine; Immunology; Antibody; Antigen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004621047,0.0003850816,0.0003684523,0.0007415246,0.0005940651,0.0006118393,0.0002601887,0.0006389542,0.0008811572],"category_scores_gemma":[0.001324103,0.0002789491,0.0003440022,0.0004329779,0.0003017025,0.0005280902,0.0003722367,0.000721072,0.0003031736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002245169,"about_ca_system_score_gemma":0.0001620817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001583332,"about_ca_topic_score_gemma":0.001103102,"domain_scores_codex":[0.9996815,0.00006011038,0.00002935061,0.0001030781,0.00005583796,0.0000701421],"domain_scores_gemma":[0.9987897,0.0001780273,0.0004442955,0.00007178768,0.0001688116,0.0003472401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001571288,0.000050167,0.9969739,0.000003044226,0.00002324538,0.0003159312,0.00009846258,0.00002206486,0.001605221,0.000007236103,0.00003636129,0.0007073102],"study_design_scores_gemma":[0.000004948001,0.000289705,0.9975647,0.000002734217,0.00001980248,0.001539465,0.0001471602,0.0001154336,0.0001987498,0.000009835829,0.0001040256,0.000003591258],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997057,0.0000650527,0.00004106009,0.0000122595,0.000002729301,0.000002725109,0.00004953434,0.000002205745,0.0001187274],"genre_scores_gemma":[0.999649,0.00003172582,0.00004089558,0.0000175574,0.000005599743,0.000003846666,0.0001499109,0.000001344475,0.000100116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001583332,"threshold_uncertainty_score":0.003148258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02066270111274196,"score_gpt":0.3137432120073273,"score_spread":0.2930805108945853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}