{"id":"W4221027434","doi":"10.1186/s13075-022-02745-6","title":"Longitudinal assessment of reactivity and affinity profile of anti-Jo1 autoantibodies to distinct HisRS domains and a splice variant in a cohort of patients with myositis and anti-synthetase syndrome","year":2022,"lang":"en","type":"article","venue":"Arthritis Research & Therapy","topic":"Inflammatory Myopathies and Dermatomyositis","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium","funders":"Reumatikerförbundet; Vetenskapsrådet; Stockholms Läns Landsting; European Federation of Pharmaceutical Industries and Associations; Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse; Ulla och Gustaf af Ugglas Stiftelse; Stiftelsen Konung Gustaf V:s 80-årsfond; Karolinska Institutet; European Commission; Bristol-Myers Squibb; Association Française contre les Myopathies; Myositis Association; Hjärt-Lungfonden; McGill University","keywords":"Autoantibody; Medicine; Immunology; Antibody; Antigen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001482055,0.0001663461,0.0007237292,0.0003583199,0.0002079335,0.00001685482,0.00008375687,0.00004405896,0.00007810744],"category_scores_gemma":[0.0000730269,0.0001450816,0.00003400852,0.000473241,0.0005220749,0.0001472801,0.0002607629,0.0003361876,1.89698e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005927131,"about_ca_system_score_gemma":0.0001963489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00113774,"about_ca_topic_score_gemma":0.0001765314,"domain_scores_codex":[0.9975448,0.0004460523,0.0004174581,0.0003930501,0.0008490806,0.0003495936],"domain_scores_gemma":[0.9987706,0.000299138,0.000153925,0.0003180606,0.0003009588,0.0001573106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009128263,0.0007710358,0.9831656,0.000258108,0.0001111535,0.0008702601,0.000849578,0.00000230036,0.006370579,0.0002622801,0.00003761346,0.006388721],"study_design_scores_gemma":[0.003923118,0.002885323,0.9901671,0.0004091364,0.00001494237,0.0005057436,0.0003870948,0.00008838423,0.001300976,0.0000394814,0.0001448108,0.0001338316],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967078,0.0008340717,0.00002110193,0.0002210259,0.00001812051,0.001494496,0.0005559624,0.00001065117,0.0001367681],"genre_scores_gemma":[0.9969558,0.002088354,0.0007269579,0.00001899493,0.000006388747,0.0001398834,0.00003668341,0.00002138109,0.000005581638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007001615,"threshold_uncertainty_score":0.5916256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02066270111274196,"score_gpt":0.3137432120073273,"score_spread":0.2930805108945853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}