{"id":"W4221030438","doi":"10.1101/2022.03.24.485591","title":"Antiviral roles of interferon regulatory factor (IRF)-1, 3 and 7 against human coronavirus infection","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Institute of Medical Science, University of Tokyo; Faculty of Medicine, Memorial University of Newfoundland; Japan Agency for Medical Research and Development; Natural Sciences and Engineering Research Council of Canada; Memorial University of Newfoundland; Canadian Institutes of Health Research; University of Ottawa","keywords":"IRF3; IRF7; Interferon regulatory factors; IRF1; Virology; Coronavirus; Biology; Interferon; Gene knockdown; Transcription factor; Coronavirus disease 2019 (COVID-19); Gene; Medicine; Genetics; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002090756,0.0002101015,0.0001698525,0.0001571783,0.0002134829,0.0002290784,0.00009356791,0.0002761608,0.002784138],"category_scores_gemma":[0.0001073339,0.00005670812,0.0003171784,0.00007732538,0.0001397834,0.0001392441,0.0001192058,0.0003596365,0.0007507184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001728906,"about_ca_system_score_gemma":0.0002276238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002992992,"about_ca_topic_score_gemma":0.000243613,"domain_scores_codex":[0.9999282,0.00001158462,0.000004398643,0.00001264121,0.00001954094,0.00002361686],"domain_scores_gemma":[0.9999686,0.000005083264,0.000006408021,0.000004782211,0.000007322707,0.000007735189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002728879,0.00002558743,0.0004931926,0.00005299176,0.000007042224,0.000044657,0.00001704953,0.00009553711,0.9949536,0.0002365297,0.0004410591,0.003359876],"study_design_scores_gemma":[0.00004380587,0.0002336749,0.01225758,0.00002060706,0.00002386083,0.0003881024,0.00006971849,0.001217542,0.9758146,0.0004091703,0.009514075,0.000007146142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98042,0.005461489,0.004476905,0.0005619486,0.000190523,0.00005724757,0.001908106,0.0002481575,0.006675727],"genre_scores_gemma":[0.9881498,0.001381466,0.003324882,0.0001383312,0.00004197902,0.00004190486,0.002251563,0.00003858977,0.004631505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002784138,"threshold_uncertainty_score":0.009313881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03893919356751603,"score_gpt":0.3093216560148249,"score_spread":0.2703824624473089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}