{"id":"W4221032819","doi":"10.1016/j.joca.2022.02.098","title":"TARGETED INHIBITION OF STAT-SIGNALING IN SYNOVIAL MACROPHAGES IN EXPERIMENTAL POST-TRAUMATIC KNEE OSTEOARTHRITIS REDUCES PAIN AND INFLAMMATION","year":2022,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Osteoarthritis; Inflammation; stat; Medicine; Signal transduction; Immunology; Pathology; Biology; Cell biology; STAT3","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003189487,0.0005101765,0.0006385253,0.000322285,0.0002898244,0.0005312536,0.0003079881,0.0004475747,0.00282954],"category_scores_gemma":[0.0001291373,0.0002446332,0.0005415481,0.0002514935,0.000609176,0.0003099922,0.0002103585,0.0013907,0.0006306394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002818088,"about_ca_system_score_gemma":0.0006598193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000570714,"about_ca_topic_score_gemma":0.001823581,"domain_scores_codex":[0.9997401,0.00002888789,0.00002058485,0.0000299389,0.00006080731,0.000119726],"domain_scores_gemma":[0.9999166,0.000008286574,0.00002564468,0.000006917283,0.000009457988,0.00003316409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007397411,0.0007006656,0.0003102638,0.0003062566,0.00004610652,0.00007274904,0.00004335758,0.0002938491,0.9844252,0.0003105062,0.0003116644,0.005781995],"study_design_scores_gemma":[0.001554139,0.01098578,0.005496124,0.00004440972,0.0002156354,0.0003766264,0.0002563925,0.001675144,0.9742596,0.0002568188,0.004854095,0.00002515604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901441,0.004435156,0.002286724,0.0004202916,0.00037783,0.00008971912,0.0005981277,0.0001151478,0.00153277],"genre_scores_gemma":[0.9916459,0.002520846,0.001559886,0.0001796597,0.00006680714,0.0001250678,0.0004753378,0.00001965903,0.003406781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00282954,"threshold_uncertainty_score":0.009465814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007660600741495943,"score_gpt":0.2271814756078442,"score_spread":0.2195208748663483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}