{"id":"W4221034867","doi":"10.1101/2022.03.13.484107","title":"Muscle calcium stress cleaves junctophilin1, unleashing a gene regulatory program predicted to correct glucose dysregulation","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Center for Research Resources; Rush University","keywords":"RYR1; Internal medicine; Endocrinology; Glycogen synthase; Biology; Calcium; Cytosol; Regulator; Glycogen; Myocyte; Transcription factor; Calcium channel; Skeletal muscle; Cell biology; GSK3B; Voltage-dependent calcium channel; GSK-3; Kinase; Ryanodine receptor; Gene; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001040964,0.0003716801,0.0001871412,0.0001605898,0.0002111563,0.0002538791,0.0001549723,0.0003032032,0.00162337],"category_scores_gemma":[0.0001209052,0.0001158577,0.0002249785,0.00008913412,0.0002262839,0.0001618707,0.0001865695,0.00044359,0.0003522806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004025371,"about_ca_system_score_gemma":0.0001738655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002911002,"about_ca_topic_score_gemma":0.0004432994,"domain_scores_codex":[0.9998952,0.000009541533,0.000009000754,0.00004569609,0.00002073949,0.00001969928],"domain_scores_gemma":[0.9998825,0.00001572453,0.000051983,0.00001270056,0.000007828412,0.00002921114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003154983,0.000007629536,0.0001083857,0.00001030177,0.000001801253,0.00004066562,0.000004053987,0.00001592229,0.9994375,0.00004180124,0.00001875975,0.0002816542],"study_design_scores_gemma":[0.00001438794,0.0001429639,0.01026245,0.000006795553,0.000008613755,0.0003388358,0.00002314845,0.0005802639,0.9870275,0.00006025469,0.001531764,0.000003186631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946558,0.001034066,0.002626657,0.0001659174,0.00006303295,0.00002804036,0.0003799134,0.00009457314,0.000951982],"genre_scores_gemma":[0.9933907,0.000416769,0.002955684,0.0001081039,0.00002296527,0.00003041,0.0007326168,0.00002936602,0.002313362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00162337,"threshold_uncertainty_score":0.005430698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01136384827959104,"score_gpt":0.23364184490743,"score_spread":0.222277996627839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}