{"id":"W4221035323","doi":"10.1172/jci158471","title":"The FoxOs are in the ApoM house","year":2022,"lang":"en","type":"letter","venue":"Journal of Clinical Investigation","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Vanderbilt University Medical Center; Vanderbilt University","keywords":"Insulin resistance; Endocrinology; Internal medicine; Metabolic syndrome; Apolipoprotein B; Biology; Lipid metabolism; Insulin; Diabetes mellitus; Medicine; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009963253,0.0005565669,0.0005211875,0.0002936395,0.001352566,0.001324713,0.0005163217,0.006628862,0.00690578],"category_scores_gemma":[0.004427994,0.0002348186,0.0005728673,0.0001745368,0.002021189,0.001653304,0.0008682073,0.01003641,0.004396384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001137083,"about_ca_system_score_gemma":0.001072681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001157636,"about_ca_topic_score_gemma":0.001852747,"domain_scores_codex":[0.9993238,0.0001227846,0.00005788519,0.0001231403,0.0002867828,0.0000855571],"domain_scores_gemma":[0.9988036,0.0004224544,0.0001148018,0.0001133743,0.0002379114,0.0003079184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003411798,0.00008690304,0.001272286,0.0001379254,0.00003242588,0.002744324,0.0001855322,0.0000551806,0.003348794,0.006738857,0.9169623,0.06809437],"study_design_scores_gemma":[0.00009042415,0.00008366218,0.001120592,0.00009118205,0.00001694001,0.00202899,0.0001688943,0.00009283726,0.0007674173,0.005613815,0.989906,0.00001924157],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.002286936,0.01347039,0.0004828506,0.8715976,0.1036236,0.0000215492,0.00008399114,0.0001494028,0.008283663],"genre_scores_gemma":[0.03843524,0.02452866,0.001470077,0.6914364,0.1862027,0.0000808741,0.0001459845,0.00008976978,0.05761035],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.00690578,"threshold_uncertainty_score":0.02310216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08489197724774487,"score_gpt":0.347899911081844,"score_spread":0.2630079338340991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}