{"id":"W4221035323","doi":"10.1172/jci158471","title":"The FoxOs are in the ApoM house","year":2022,"lang":"en","type":"letter","venue":"Journal of Clinical Investigation","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Vanderbilt University Medical Center; Vanderbilt University","keywords":"Insulin resistance; Endocrinology; Internal medicine; Metabolic syndrome; Apolipoprotein B; Biology; Lipid metabolism; Insulin; Diabetes mellitus; Medicine; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002937164,0.0001498872,0.0002689678,0.00005906754,0.0001349825,0.00007583699,0.0006044817,0.000507524,0.00001801167],"category_scores_gemma":[0.00135493,0.00008809729,0.0003648378,0.0001241175,0.0002490564,0.000009681299,0.00003629581,0.002102807,0.000004669095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002803299,"about_ca_system_score_gemma":0.000223189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006264391,"about_ca_topic_score_gemma":0.00003364249,"domain_scores_codex":[0.9964245,0.001339896,0.001311466,0.0001864486,0.0005806961,0.0001569777],"domain_scores_gemma":[0.9974214,0.0004281796,0.001564253,0.0003771498,0.0001664558,0.00004252958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007690878,0.00002452138,0.005332693,0.00001492022,0.00005796558,0.00003016836,0.0000581282,0.0001242972,0.0007589257,0.00001986114,0.9927549,0.000746691],"study_design_scores_gemma":[0.000459444,0.0003763302,0.02989279,0.00003258356,0.00004712569,0.00004101013,0.00007393926,0.00002441101,0.000226659,0.001049053,0.9676722,0.0001044723],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.2551066,0.0007931046,0.0000987315,0.7416965,0.001919717,0.0002789013,0.00001438566,0.000006275226,0.00008574551],"genre_scores_gemma":[0.246541,0.001093894,0.0002368979,0.7386643,0.01230693,0.00003043578,0.0002590094,0.00008294477,0.0007846447],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02508274,"threshold_uncertainty_score":0.9135765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08489197724774487,"score_gpt":0.347899911081844,"score_spread":0.2630079338340991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}