{"id":"W4221039321","doi":"10.1164/rccm.202111-2493oc","title":"CD4<sup>+</sup> T-Cell Dysfunction in Severe COVID-19 Disease Is Tumor Necrosis Factor-α/Tumor Necrosis Factor Receptor 1-Dependent.","year":2022,"lang":"en","type":"article","venue":"PubMed","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Pittsburgh Foundation","keywords":"Tumor necrosis factor alpha; Medicine; Immunology; CD8; T cell; Peripheral blood mononuclear cell; Cytokine; Flow cytometry; Immune system; Receptor; Internal medicine; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007784453,0.0003328612,0.0004100873,0.0002711575,0.0002586243,0.0003868487,0.0002239387,0.0003106016,0.007126582],"category_scores_gemma":[0.0007662898,0.000100951,0.0002278742,0.0003135103,0.0003018821,0.0003052668,0.0002497868,0.000543631,0.001005911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002612192,"about_ca_system_score_gemma":0.0003207689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005318839,"about_ca_topic_score_gemma":0.0007420633,"domain_scores_codex":[0.9997808,0.00008163707,0.00002485652,0.00002301718,0.00002979184,0.00005983973],"domain_scores_gemma":[0.9993865,0.0001057502,0.0001546791,0.00007154958,0.00009634902,0.0001851247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03741662,0.002645202,0.2806118,0.001837876,0.0003477128,0.005522707,0.0004110246,0.0005679154,0.4462322,0.001229107,0.01401005,0.2091679],"study_design_scores_gemma":[0.002048092,0.03719335,0.7884056,0.0004394159,0.0004115756,0.01750835,0.0008967628,0.001268563,0.1122831,0.001424256,0.03806131,0.00005958181],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.976582,0.006842868,0.001207258,0.0008769748,0.0002041462,0.0003874204,0.001638493,0.00008346282,0.01217736],"genre_scores_gemma":[0.9935076,0.00134278,0.0009145736,0.0003215448,0.00009156277,0.0001085597,0.001615416,0.00001337527,0.002084523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007126582,"threshold_uncertainty_score":0.02384073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05372483473166716,"score_gpt":0.3265419003368173,"score_spread":0.2728170656051501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}