{"id":"W4221040490","doi":"10.1038/s41421-022-00385-3","title":"ALKBH3-dependent m1A demethylation of Aurora A mRNA inhibits ciliogenesis","year":2022,"lang":"en","type":"article","venue":"Cell Discovery","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Higher Education Discipline Innovation Project; Peking University; Zhejiang University; University of Chicago; National Natural Science Foundation of China; Chinese Academy of Sciences","keywords":"Ciliogenesis; Cilium; Zebrafish; Cell biology; Somitogenesis; Ectopic expression; Messenger RNA; Biology; Demethylase; Embryo; Embryogenesis; Genetics; Epigenetics; Gene; Somite","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001122574,0.0002734626,0.0002152722,0.0001689724,0.0001985229,0.0001786473,0.0001871079,0.0002437899,0.001863356],"category_scores_gemma":[0.0001132507,0.0001382363,0.000235844,0.00009773712,0.0002651784,0.0001168298,0.0002240634,0.0004859038,0.0003891803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000285705,"about_ca_system_score_gemma":0.0002440931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009655364,"about_ca_topic_score_gemma":0.001673441,"domain_scores_codex":[0.9998984,0.00001107859,0.00001038552,0.00002079221,0.00002699837,0.0000322521],"domain_scores_gemma":[0.9999163,0.00002059716,0.00002338455,0.00001289301,0.000007943843,0.00001888386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006814561,0.00001088318,0.0001374941,0.00002049393,0.000004078001,0.00001915106,0.000004317998,0.00004159176,0.9991353,0.00006044326,0.00003183767,0.0004662863],"study_design_scores_gemma":[0.00001089585,0.00009779411,0.002665774,0.000002118429,0.000006384601,0.00006774645,0.0000121231,0.0004687838,0.9955722,0.00003620951,0.001057768,0.000002161089],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939418,0.00155277,0.00188951,0.000117408,0.00004118388,0.00002115064,0.0003749179,0.0001268226,0.001934444],"genre_scores_gemma":[0.9971973,0.0002920885,0.0005784931,0.00004020964,0.00000501255,0.00001470751,0.000325407,0.00001236808,0.001534475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001863356,"threshold_uncertainty_score":0.006233573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008834763520962132,"score_gpt":0.218838650324614,"score_spread":0.2100038868036518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}