{"id":"W4221040490","doi":"10.1038/s41421-022-00385-3","title":"ALKBH3-dependent m1A demethylation of Aurora A mRNA inhibits ciliogenesis","year":2022,"lang":"en","type":"article","venue":"Cell Discovery","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Higher Education Discipline Innovation Project; Peking University; Zhejiang University; University of Chicago; National Natural Science Foundation of China; Chinese Academy of Sciences","keywords":"Ciliogenesis; Cilium; Zebrafish; Cell biology; Somitogenesis; Ectopic expression; Messenger RNA; Biology; Demethylase; Embryo; Embryogenesis; Genetics; Epigenetics; Gene; Somite","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000143427,0.00008578492,0.00008865349,0.00004822328,0.0001026302,0.00001447003,0.000153067,0.00004012278,0.0001139229],"category_scores_gemma":[0.00001041877,0.00009019142,0.00008885423,0.0001241914,0.00002969733,0.000007099678,0.000159523,0.00005249325,0.000004546281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002779395,"about_ca_system_score_gemma":0.0001115894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004010632,"about_ca_topic_score_gemma":0.00001039904,"domain_scores_codex":[0.9992161,0.00005875563,0.0001787341,0.0002423257,0.0001692884,0.0001347829],"domain_scores_gemma":[0.9994985,0.000005934993,0.0001093584,0.0003170096,0.00003664528,0.00003251986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005661017,0.000106944,0.001439798,0.00001535014,0.0000185292,7.855753e-7,0.00004060176,0.003236446,0.9922505,0.00007831199,0.001306779,0.001449369],"study_design_scores_gemma":[0.0003552863,0.0001380397,0.003025229,0.000002310258,0.00002223372,0.000002502612,0.0002361693,0.00005519938,0.9717901,0.00007340008,0.02416554,0.0001340093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923443,0.002251924,0.002425218,0.00004701925,0.0001434674,0.0001249945,0.0001015489,0.000005183782,0.002556307],"genre_scores_gemma":[0.9946526,0.0002383366,0.0001344651,0.0001002772,0.00007130541,0.00007134747,0.0001742239,0.00001566715,0.00454178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02285876,"threshold_uncertainty_score":0.36779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008834763520962132,"score_gpt":0.218838650324614,"score_spread":0.2100038868036518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}