{"id":"W4221044842","doi":"10.1158/1538-7445.sabcs21-pd8-01","title":"Abstract PD8-01: Phase 3 SOPHIA study of margetuximab (M) + chemotherapy (CTX) vs trastuzumab (T) + CTX in patients (pts) with HER2+ metastatic breast cancer (MBC) after prior anti-HER2 therapies: Final overall survival (OS) analysis","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Regional Municipality of Durham; Lakeridge Health","funders":"","keywords":"Pertuzumab; Medicine; Trastuzumab; Metastatic breast cancer; Internal medicine; Oncology; Gastroenterology; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001194741,0.0007021778,0.001079488,0.0001948416,0.0001827464,0.0007186096,0.0005248164,0.0005809015,0.002844808],"category_scores_gemma":[0.0006333659,0.0003136278,0.001855072,0.0001847805,0.0003932829,0.0003348543,0.0003076178,0.001863994,0.0005445417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008049127,"about_ca_system_score_gemma":0.000767039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001512812,"about_ca_topic_score_gemma":0.004052796,"domain_scores_codex":[0.9996018,0.0002429499,0.00001866523,0.0000575594,0.00003585511,0.00004319823],"domain_scores_gemma":[0.9996141,0.00006829854,0.0001162405,0.00003117603,0.00002706464,0.0001431602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8603162,0.01283874,0.01445247,0.0008791457,0.004475648,0.0001114411,0.0001867337,0.002429371,0.01817907,0.0002931372,0.006382178,0.07945592],"study_design_scores_gemma":[0.4332316,0.4795748,0.06801159,0.0001348214,0.004750256,0.0003737859,0.0001151948,0.002712858,0.003989474,0.0003407174,0.006709632,0.00005528269],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908742,0.002588194,0.0003642112,0.0004999259,0.0001121119,0.0007792207,0.002014594,0.00007639084,0.002691186],"genre_scores_gemma":[0.9910533,0.001204268,0.0008204131,0.0008596901,0.0001244072,0.0006513095,0.002608788,0.00001843742,0.002659381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002844808,"threshold_uncertainty_score":0.009516835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05967525828412634,"score_gpt":0.4021295240335063,"score_spread":0.34245426574938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}