{"id":"W4221045372","doi":"10.1038/s41598-022-08387-7","title":"Blood–brain barrier and gut barrier dysfunction in chronic kidney disease with a focus on circulating biomarkers and tight junction proteins","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; McGill University Health Centre","funders":"Center for Innovative Medicine; Njurfonden; Vetenskapsrådet; Karolinska Institutet; Hjärt-Lungfonden","keywords":"Occludin; Tight junction; Blood–brain barrier; Kidney disease; Claudin; Endocrinology; Trimethylamine N-oxide; Internal medicine; Medicine; Enolase; Kidney; Pathology; Chemistry; Biology; Central nervous system; Cell biology; Biochemistry; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002365369,0.0002997201,0.0004234682,0.0005479922,0.0002899858,0.0005082805,0.0001389932,0.0004129904,0.0009581543],"category_scores_gemma":[0.000216706,0.00008924265,0.0002571035,0.00049789,0.0002007271,0.0003300838,0.0003632513,0.0005303055,0.0001055432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003342802,"about_ca_system_score_gemma":0.0002860092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001734959,"about_ca_topic_score_gemma":0.002677161,"domain_scores_codex":[0.9998639,0.0000338291,0.00001921062,0.00002855226,0.00003225176,0.00002229664],"domain_scores_gemma":[0.999855,0.00001616957,0.00006500238,0.000007071155,0.0000284018,0.00002842101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006791087,0.00100341,0.6054803,0.00414418,0.001097766,0.002434355,0.0005982181,0.0005892655,0.1805626,0.001629291,0.003717796,0.1919518],"study_design_scores_gemma":[0.00004450492,0.0009776652,0.981463,0.0002154147,0.0002806726,0.002461296,0.0001914274,0.0006510441,0.006989332,0.0005536148,0.006151075,0.00002099168],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8747543,0.1173956,0.002387865,0.0007066458,0.0001100614,0.00007339423,0.0006077639,0.00006654853,0.003897922],"genre_scores_gemma":[0.9795298,0.01583439,0.002353951,0.0003089621,0.0001200418,0.000075476,0.0004497984,0.000006164736,0.001321488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001734959,"threshold_uncertainty_score":0.003449738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01188436720550409,"score_gpt":0.2223543380698262,"score_spread":0.2104699708643221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}