{"id":"W4221046881","doi":"10.1021/acs.inorgchem.2c00057","title":"Cu(I) Binding to Designed Proteins Reveals a Putative Copper Binding Site of the Human Line1 Retrotransposon Protein ORF1p","year":2022,"lang":"en","type":"article","venue":"Inorganic Chemistry","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"SLAC National Accelerator Laboratory; Basic Energy Sciences; National Institute of Environmental Health Sciences; National Institute of General Medical Sciences; Biological and Environmental Research; Natural Sciences and Engineering Research Council of Canada; Office of Science; National Institutes of Health; U.S. Department of Energy","keywords":"Chemistry; Cysteine; Coiled coil; Crystallography; Stereochemistry; Binding site; Metalloprotein; Metal; Biochemistry; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007666362,0.0002829288,0.0001957766,0.00008330922,0.0000937005,0.0001632636,0.0002166525,0.0003059098,0.0007313396],"category_scores_gemma":[0.0001633363,0.0001202529,0.0001793045,0.0001111279,0.00012789,0.0001006311,0.0001193203,0.0002808087,0.0002428139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003067419,"about_ca_system_score_gemma":0.00008103831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004294541,"about_ca_topic_score_gemma":0.0004877034,"domain_scores_codex":[0.9998966,0.00001680018,0.000005574395,0.000030578,0.0000284555,0.00002184157],"domain_scores_gemma":[0.9999138,0.00001991066,0.0000293992,0.000004923954,0.00001134577,0.00002057053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008394718,0.00001323944,0.0002744808,0.00002078524,0.000004273982,0.0000606416,0.00001966883,0.0001222365,0.9988428,0.00001793497,0.00001788333,0.0005219936],"study_design_scores_gemma":[0.00001142981,0.0002211744,0.006098247,0.000003989811,0.000008989669,0.0002663924,0.00003335929,0.00207841,0.9905766,0.00002591217,0.000669146,0.000006233462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984384,0.0001453244,0.001014433,0.00002447753,0.000003851876,0.000004680387,0.00007605227,0.00003113452,0.0002615765],"genre_scores_gemma":[0.9967373,0.00008927675,0.00219101,0.00003514386,0.000002217512,0.000007174789,0.0002863096,0.00001364244,0.0006379756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007313396,"threshold_uncertainty_score":0.002446592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01276475278524138,"score_gpt":0.2417008989078095,"score_spread":0.2289361461225681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}