{"id":"W4221049586","doi":"10.1158/1055-9965.epi-21-0724","title":"Genetic Regulation of DNA Methylation Yields Novel Discoveries in GWAS of Colorectal Cancer","year":2022,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Lunenfeld-Tanenbaum Research Institute; Hospital for Sick Children","funders":"Office of Research Infrastructure Programs, National Institutes of Health; U.S. Department of Health and Human Services; National Institutes of Health; National Cancer Institute; Fred Hutchinson Cancer Research Center; World Health Organization","keywords":"Colorectal cancer; Genome-wide association study; dNaM; DNA methylation; Genome; Methylation; Genetic association","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003983549,0.0004422651,0.0005948526,0.0007210579,0.00027228,0.0008323277,0.0004564906,0.0004516698,0.003094642],"category_scores_gemma":[0.0117009,0.0003385727,0.001033979,0.001253332,0.0005856976,0.0003553834,0.0007068834,0.0005904954,0.0003010609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002719344,"about_ca_system_score_gemma":0.000414773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001727959,"about_ca_topic_score_gemma":0.002323778,"domain_scores_codex":[0.9980032,0.0008827801,0.000124874,0.00065489,0.0002334909,0.0001007244],"domain_scores_gemma":[0.9930207,0.00404611,0.001385652,0.001041922,0.000260103,0.0002455458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008965894,0.00003023947,0.9364577,0.0001518944,0.00196035,0.0003257681,0.00008950299,0.003001262,0.02525417,0.0009849663,0.0005353331,0.03031228],"study_design_scores_gemma":[0.00005002727,0.000304036,0.9664829,0.00002606709,0.001275438,0.0007541234,0.00007506603,0.01970696,0.006021063,0.003484493,0.001784876,0.00003488052],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9590839,0.00164521,0.034926,0.0005724403,0.00003094866,0.00002195924,0.001565284,0.0007433625,0.001410798],"genre_scores_gemma":[0.9946058,0.0001427581,0.004468143,0.00008752229,0.0000251845,0.000007940989,0.000369097,0.00004669854,0.0002468798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003983549,"threshold_uncertainty_score":0.02106726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03341448657633752,"score_gpt":0.3353153369500504,"score_spread":0.3019008503737129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}