{"id":"W4221054193","doi":"10.3390/curroncol29040189","title":"A Pleiotropic Role of Long Non-Coding RNAs in the Modulation of Wnt/β-Catenin and PI3K/Akt/mTOR Signaling Pathways in Esophageal Squamous Cell Carcinoma: Implication in Chemotherapeutic Drug Response","year":2022,"lang":"en","type":"review","venue":"Current Oncology","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"PI3K/AKT/mTOR pathway; Wnt signaling pathway; Protein kinase B; Cancer research; Gefitinib; Medicine; Metastasis; Catenin; Signal transduction; Cisplatin; Paclitaxel; Cancer; Biology; Internal medicine; Chemotherapy; Epidermal growth factor receptor; Cell biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0013426,0.0002760983,0.0007988346,0.0005033953,0.00003719983,0.000009328864,0.0004840774,0.000346582,0.00001520487],"category_scores_gemma":[0.000139891,0.0002569329,0.0001640769,0.0005371417,0.00008040186,0.000005485009,0.0002982253,0.0006772905,6.706427e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004056725,"about_ca_system_score_gemma":0.0007371941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001149463,"about_ca_topic_score_gemma":0.0001288473,"domain_scores_codex":[0.9967605,0.001296421,0.0008108867,0.0005561154,0.0002319187,0.0003441998],"domain_scores_gemma":[0.9987955,0.0002535836,0.0004741648,0.0003839893,0.00005077303,0.0000419713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006490974,0.0007326759,0.0002598081,0.004717521,0.00002659902,0.00003654098,0.001640159,0.00031046,0.365005,0.00003871522,0.00001081325,0.6265727],"study_design_scores_gemma":[0.02355053,0.008769874,0.01584017,0.005845326,0.001121599,0.0005042098,0.004113828,0.0110665,0.7236066,0.0009454199,0.2010558,0.003580228],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3434279,0.6549792,0.0003069667,0.00001681139,0.00008924808,0.001131678,0.0000238936,0.000002358689,0.00002196187],"genre_scores_gemma":[0.7298595,0.2695407,0.00002874202,0.000005381223,0.00004140245,0.0003096946,0.0001774993,0.00003215766,0.000004941352],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.6229924,"threshold_uncertainty_score":0.9999883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06016938706726134,"score_gpt":0.3625612626190823,"score_spread":0.302391875551821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}