{"id":"W4221054193","doi":"10.3390/curroncol29040189","title":"A Pleiotropic Role of Long Non-Coding RNAs in the Modulation of Wnt/β-Catenin and PI3K/Akt/mTOR Signaling Pathways in Esophageal Squamous Cell Carcinoma: Implication in Chemotherapeutic Drug Response","year":2022,"lang":"en","type":"review","venue":"Current Oncology","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"PI3K/AKT/mTOR pathway; Wnt signaling pathway; Protein kinase B; Cancer research; Gefitinib; Medicine; Metastasis; Catenin; Signal transduction; Cisplatin; Paclitaxel; Cancer; Biology; Internal medicine; Chemotherapy; Epidermal growth factor receptor; Cell biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001715624,0.0002854983,0.0002861423,0.000418978,0.0001752619,0.0004613613,0.0001306116,0.0002538721,0.001013037],"category_scores_gemma":[0.0001669303,0.0001271748,0.0004114257,0.000323612,0.0002253027,0.0002651352,0.0002245964,0.0004068298,0.000174034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003314122,"about_ca_system_score_gemma":0.0003311675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004395766,"about_ca_topic_score_gemma":0.0009239379,"domain_scores_codex":[0.9998773,0.00001722062,0.00002093821,0.00003622828,0.00003077144,0.00001752458],"domain_scores_gemma":[0.9999056,0.00002230863,0.0000362829,0.000004851215,0.00001825136,0.00001273341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004924131,0.00005640472,0.008370575,0.002039175,0.0001776278,0.001431768,0.0001606773,0.0005356652,0.9113916,0.001147389,0.001094891,0.07310178],"study_design_scores_gemma":[0.000130796,0.001289605,0.2280157,0.0004262592,0.001181316,0.005648552,0.0005380021,0.003359346,0.6774952,0.001893464,0.07991215,0.0001095729],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.5531555,0.4249931,0.008690282,0.001164058,0.0003466317,0.00008365016,0.001417084,0.0003221227,0.009827471],"genre_scores_gemma":[0.8791078,0.1110859,0.003579899,0.0005781626,0.0001126979,0.00008625424,0.0009613295,0.00004490603,0.004443063],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001013037,"threshold_uncertainty_score":0.003388941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06016938706726134,"score_gpt":0.3625612626190823,"score_spread":0.302391875551821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}