{"id":"W4221056009","doi":"10.1158/1538-7445.sabcs21-gs1-08","title":"Abstract GS1-08: CCTGMA.32, a phase III randomized double-blind placebo controlled adjuvant trial of metformin (MET) vs placebo (PLAC) in early breast cancer (BC): Results of the primary efficacy analysis (clinical trials.gov NCT01101438)","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Risks and Factors","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Statistics Canada; Juravinski Cancer Centre; University of British Columbia; McMaster University; Queen's University; Princess Margaret Cancer Centre; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; BC Cancer Agency; University Health Network; University of Toronto","funders":"","keywords":"Medicine; Metformin; Breast cancer; Placebo; Internal medicine; Cancer; Randomized controlled trial; Oncology; Clinical trial; Diabetes mellitus; Endocrinology; Insulin; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.05699323,0.0005146936,0.00754909,0.001649223,0.000306166,0.00006355104,0.0008606797,0.0003331278,0.003349033],"category_scores_gemma":[0.004988432,0.0003298822,0.003066703,0.003937612,0.001159632,0.0001597955,0.0005104679,0.002799552,0.000005877887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00140166,"about_ca_system_score_gemma":0.005598583,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.06753797,"about_ca_topic_score_gemma":0.005970797,"domain_scores_codex":[0.9819764,0.006503719,0.005683681,0.001151173,0.003605235,0.001079742],"domain_scores_gemma":[0.9800072,0.01487865,0.002334905,0.001443199,0.0008477974,0.0004882023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9729634,0.003180564,0.001128342,0.0001634708,0.005865681,0.00006123715,0.001238792,0.001264092,0.001241209,0.00003408012,0.002993245,0.009865885],"study_design_scores_gemma":[0.9837982,0.001746354,0.005903626,0.0002848033,0.003724977,0.000006814951,0.0004171189,0.0008445784,0.001160499,0.0000145903,0.001791665,0.0003067511],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9740418,0.002186764,0.00001296194,0.001581487,0.0009557841,0.01793836,0.002078068,0.00002926157,0.00117556],"genre_scores_gemma":[0.9903512,0.002106482,0.00001680487,0.00008101256,0.0007641987,0.004805844,0.0001486063,0.0000707463,0.00165511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06156717,"threshold_uncertainty_score":0.9999153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1888491423211349,"score_gpt":0.5005900067145773,"score_spread":0.3117408643934424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}