{"id":"W4221058334","doi":"10.1101/2022.03.27.486008","title":"A complete MAPK cascade, a calmodulin, and a protein phosphatase act downstream of CRK receptor kinases and regulate <i>Arabidopsis</i> innate immunity","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Plant-Microbe Interactions and Immunity","field":"Agricultural and Biological Sciences","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; China Scholarship Council","keywords":"MAPK cascade; MAPK/ERK pathway; Pseudomonas syringae; Arabidopsis; Kinase; Biology; Cell biology; MAP kinase kinase kinase; Adapter molecule crk; Phosphatase; Protein kinase A; Signal transduction; Mitogen-activated protein kinase kinase; Innate immune system; Phosphorylation; Biochemistry; Signal transducing adaptor protein; Receptor; Microbiology; Pathogen; Mutant; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000126375,0.0008077618,0.0002424991,0.0002324449,0.0002261582,0.000309065,0.000330462,0.0003309557,0.002725274],"category_scores_gemma":[0.0000853605,0.0002085973,0.0004125752,0.0001043524,0.0002244998,0.0003492598,0.000334923,0.0006136082,0.001409423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000674525,"about_ca_system_score_gemma":0.0002637269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005349329,"about_ca_topic_score_gemma":0.0008073424,"domain_scores_codex":[0.9998271,0.000013541,0.00000952511,0.00005565522,0.00004314052,0.00005107098],"domain_scores_gemma":[0.9999236,0.000005145954,0.00002158826,0.00000769577,0.00001178806,0.00003023993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007390789,0.00001313859,0.0001258428,0.00004157383,0.000004552835,0.00006064106,0.000002429316,0.00005088735,0.9982893,0.0001778674,0.00009371612,0.00106624],"study_design_scores_gemma":[0.00008656053,0.0001634599,0.01549421,0.00001002713,0.00002808714,0.0007298222,0.00001566646,0.003840498,0.9722412,0.0003053313,0.007073417,0.00001176469],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9455766,0.01008145,0.02866553,0.0007296,0.0002695254,0.0002594023,0.002069041,0.00128162,0.01106738],"genre_scores_gemma":[0.9815859,0.001459879,0.008896973,0.0001650551,0.00005304557,0.0001129087,0.001363879,0.00005649645,0.006305984],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002725274,"threshold_uncertainty_score":0.009116948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01586090152997619,"score_gpt":0.2063101946335748,"score_spread":0.1904492931035986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}