{"id":"W4221058645","doi":"10.1002/chem.202104484","title":"Sandacrabins – Structurally Unique Antiviral RNA Polymerase Inhibitors from a Rare Myxobacterium**","year":2022,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"RNA; Polymerase; Enzyme; RNA polymerase; Biology; Biochemistry; RNA-dependent RNA polymerase; Genome; Chemistry; Nucleoside; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007406007,0.0003191281,0.000181993,0.0002286819,0.0001087822,0.0002092453,0.0001506063,0.0002072628,0.0007689221],"category_scores_gemma":[0.00009218542,0.00009612973,0.000152021,0.0001543073,0.0001285247,0.0001779211,0.000221765,0.0002869164,0.0003172813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001498444,"about_ca_system_score_gemma":0.000184832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00035581,"about_ca_topic_score_gemma":0.001287846,"domain_scores_codex":[0.9999651,0.000004721155,0.000004477255,0.000007571385,0.00001023533,0.000007825401],"domain_scores_gemma":[0.9999565,0.000005063153,0.00000989331,0.000006533076,0.000007134036,0.0000148096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001051936,0.00002047957,0.0001827816,0.0001497069,0.000008794415,0.00009351547,0.00002212833,0.0002130375,0.9886873,0.0001504354,0.00006497141,0.01030159],"study_design_scores_gemma":[0.00005847806,0.001526503,0.005082831,0.00005696707,0.00005001617,0.0008730441,0.00006284667,0.0008592052,0.9637268,0.0002451669,0.0274356,0.00002250024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9661758,0.01653679,0.006680082,0.0002255413,0.00008664022,0.0001910182,0.001011424,0.0001651935,0.008927508],"genre_scores_gemma":[0.9831662,0.004865445,0.00759286,0.0001034415,0.0000228948,0.00004688658,0.001138622,0.00001653766,0.003047104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007689221,"threshold_uncertainty_score":0.002572298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007938651917219677,"score_gpt":0.204001381434164,"score_spread":0.1960627295169443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}