{"id":"W4221060483","doi":"10.1515/cclm-2021-1113","title":"Prognostic significance of blood-based multi-cancer detection in plasma cell-free DNA","year":2021,"lang":"en","type":"letter","venue":"Clinical Chemistry and Laboratory Medicine (CCLM)","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Mount Sinai Hospital","funders":"","keywords":"Clinical significance; Cell-free fetal DNA; Circulating tumor DNA; Medicine; DNA; Cancer detection; Oncology; Cancer; Internal medicine; Pathology; Cancer research; Chemistry; Biology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001350765,0.0002983684,0.0005119372,0.0007308132,0.0005696174,0.001116285,0.0003872466,0.003868777,0.002144775],"category_scores_gemma":[0.01069394,0.0001952622,0.0001714728,0.0005630178,0.0006230705,0.0004850539,0.0003151291,0.002604424,0.001718244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006881432,"about_ca_system_score_gemma":0.0002816042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001090618,"about_ca_topic_score_gemma":0.001088922,"domain_scores_codex":[0.9986576,0.0005012036,0.0001059375,0.0002076636,0.0002813333,0.0002462215],"domain_scores_gemma":[0.9927246,0.004966003,0.0004229491,0.0002853782,0.0009594239,0.0006417501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008315151,0.0003582827,0.6268734,0.000245234,0.0001209289,0.04864848,0.0005563103,0.0009119317,0.01486419,0.002797559,0.1655121,0.1307964],"study_design_scores_gemma":[0.0008080446,0.002667183,0.5421534,0.0007369562,0.0004260801,0.1831656,0.00147858,0.02379197,0.02635066,0.02103437,0.1970899,0.0002972046],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5723913,0.01521762,0.004295643,0.3484463,0.01509821,0.00007642382,0.001854096,0.0003212867,0.04229894],"genre_scores_gemma":[0.9360222,0.001575108,0.001311349,0.04377744,0.01030125,0.0000322169,0.0004079745,0.00004833932,0.00652415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003868777,"threshold_uncertainty_score":0.007175028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02450236679632137,"score_gpt":0.2947923052315113,"score_spread":0.2702899384351899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}