{"id":"W4221060919","doi":"10.1136/jitc-2021-004191","title":"Immune system and intestinal microbiota determine efficacy of androgen deprivation therapy against prostate cancer","year":2022,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Cancer Institute; Labex Immuno-Oncology; Horizon 2020 Framework Programme; Institut Carnot Santé Animale; Institut Universitaire de France; Ligue Contre le Cancer; Fondation pour la Recherche Médicale; Institut National Du Cancer; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Université de Paris; Association pour la Recherche sur le Cancer; Seerave Foundation; Institut Gustave-Roussy; Fondation Leducq; European Commission; Centre National de la Recherche Scientifique; National Institutes of Health; Equipex","keywords":"Prostate cancer; Medicine; Akkermansia; Immune system; Androgen deprivation therapy; Immunology; Cancer; Internal medicine; Cancer research; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001424135,0.0001698366,0.0002568533,0.0002801479,0.0001020455,0.000239432,0.0000832846,0.0001459967,0.001024489],"category_scores_gemma":[0.0002679849,0.00008815451,0.0001577891,0.000162583,0.0001461671,0.0001650711,0.0001512186,0.0003163329,0.0001389742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001411714,"about_ca_system_score_gemma":0.0001401332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003428709,"about_ca_topic_score_gemma":0.0004838154,"domain_scores_codex":[0.999881,0.00003365607,0.000007843795,0.00002131427,0.00002457915,0.00003151923],"domain_scores_gemma":[0.9997893,0.00003845553,0.00004743016,0.000009789776,0.0000203938,0.00009471249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.008374475,0.0008247916,0.1257056,0.0001440401,0.00009189434,0.0001693739,0.00008870745,0.0003943529,0.8311723,0.00007662566,0.0001930124,0.03276499],"study_design_scores_gemma":[0.0001086683,0.01524099,0.8795726,0.00002287349,0.0002001891,0.0008886485,0.0001725822,0.0009475343,0.1008038,0.00008535716,0.001943259,0.00001349596],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974565,0.001746223,0.0001442308,0.00001843209,0.000007032168,0.00001507775,0.00008724545,0.000007866114,0.0005174014],"genre_scores_gemma":[0.9992203,0.0003920996,0.0001013439,0.00001830388,0.000007016549,0.000008595216,0.00009786885,0.000001935901,0.0001526064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001024489,"threshold_uncertainty_score":0.003427267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01269978521263206,"score_gpt":0.2939193504528897,"score_spread":0.2812195652402577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}