{"id":"W4221061009","doi":"10.1016/j.amjmed.2022.02.016","title":"Effect of Alirocumab on Incidence of Atrial Fibrillation After Acute Coronary Syndromes: Insights from the ODYSSEY OUTCOMES Trial","year":2022,"lang":"en","type":"article","venue":"The American Journal of Medicine","topic":"Atrial Fibrillation Management and Outcomes","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian VIGOUR Centre; University of Toronto; St. Michael's Hospital; University of Alberta","funders":"Eisai Incorporated; American Regent; Seventh Framework Programme; St. Jude Medical; National Institutes of Health; Esperion Therapeutics; Silence Therapeutics; Cardiological Society of India; Idorsia Pharmaceuticals; Janssen Pharmaceuticals; Medtronic; Novo Nordisk; Eisai; Hartstichting; Daiichi-Sankyo; DalCor Pharmaceuticals; Novartis; Belvoir Media Group; Regado Biosciences; Ironwood Pharmaceuticals, Incorporated; Medicines Company; Regeneron Pharmaceuticals; Boston VA Research Institute; Boston Scientific Corporation; F. Hoffmann-La Roche; Servier; Abbott Laboratories; Bayer; Gilead Sciences; Bristol-Myers Squibb; Cleveland Clinic; Boehringer Ingelheim; American College of Cardiology Foundation; Sanofi; GlaxoSmithKline; Mayo Clinic; Merck; Icahn School of Medicine at Mount Sinai; HLS Therapeutics; Pfizer; Eli Lilly and Company; Biotronik; Amarin Corporation; Genentech; AstraZeneca; Roche; Duke Clinical Research Institute; Astellas Pharma US; Amgen; Ariad Pharmaceuticals; European Society of Cardiology; Chiesi Farmaceutici; American Heart Association; CSL Behring; U.S. Department of Veterans Affairs","keywords":"Medicine; Atrial fibrillation; Internal medicine; Cardiology; Acute coronary syndrome; Hazard ratio; Myocardial infarction; Mace; Alirocumab; Stroke (engine); Confidence interval; Percutaneous coronary intervention; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003613411,0.0006418331,0.001626552,0.0002738796,0.0002934111,0.0009898876,0.0005327699,0.0007960785,0.001865643],"category_scores_gemma":[0.00750153,0.0001654018,0.001783143,0.000441119,0.0003933804,0.0006234937,0.0006871592,0.001410177,0.0001411207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004623307,"about_ca_system_score_gemma":0.0005849565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001318809,"about_ca_topic_score_gemma":0.002601829,"domain_scores_codex":[0.9978396,0.001336187,0.0001878745,0.0002507056,0.0002174855,0.0001682607],"domain_scores_gemma":[0.9955992,0.001836335,0.001544667,0.0002088056,0.0002791518,0.0005318586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5340191,0.00296052,0.2852061,0.006502671,0.02947011,0.0002497924,0.0002852286,0.001931209,0.001067256,0.001504997,0.008478567,0.1283244],"study_design_scores_gemma":[0.2237172,0.0273785,0.699029,0.00199639,0.02908924,0.0005069213,0.0002341825,0.003715305,0.0008771052,0.00338558,0.009937477,0.0001331505],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9431686,0.04715048,0.0004174705,0.002132839,0.0002531564,0.0002431989,0.002556372,0.00003753554,0.004040234],"genre_scores_gemma":[0.9889815,0.006569841,0.0004591217,0.0009521617,0.0003457752,0.0003144829,0.001916903,0.000008955033,0.0004512026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003613411,"threshold_uncertainty_score":0.01910979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02504236497042671,"score_gpt":0.334816359363193,"score_spread":0.3097739943927663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}