{"id":"W4221063264","doi":"10.1101/2022.03.07.483294","title":"Attenuation of a DNA Cruciform by a Conserved Regulator Directs T3SS-1 mediated virulence in <i>Vibrio parahaemolyticus</i>","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Vibrio bacteria research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Killam Trusts","keywords":"Biology; Virulence; Vibrio parahaemolyticus; Cruciform; Gene; Genetics; Promoter; Vibrio; Regulation of gene expression; DNA; Gene expression; Molecular biology; Cell biology; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001507336,0.0002903706,0.0001461367,0.00008498997,0.0001098751,0.0002013525,0.0001525299,0.0001650348,0.0007045191],"category_scores_gemma":[0.0001635831,0.0000808735,0.0001761593,0.00005476217,0.0002085806,0.0001073156,0.0002611388,0.0003702065,0.0002817607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003486701,"about_ca_system_score_gemma":0.0001889673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006988888,"about_ca_topic_score_gemma":0.0006784012,"domain_scores_codex":[0.999874,0.00002595107,0.000007901988,0.00003009418,0.00003256993,0.00002955621],"domain_scores_gemma":[0.999873,0.00002586092,0.00004419661,0.00001458476,0.00001594911,0.00002625229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003087021,0.000009719154,0.0001125953,0.000007393322,6.647438e-7,0.00001456317,0.000005560351,0.00002753428,0.9995314,0.00004506099,0.000007943231,0.0002067237],"study_design_scores_gemma":[0.000006611872,0.0001491909,0.002321496,0.000003854876,0.000003693397,0.0001041635,0.00002090553,0.001188416,0.9955996,0.00003744123,0.0005621021,0.000002473633],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957624,0.0002533908,0.003227796,0.00004639955,0.00001294156,0.00001403372,0.0001010793,0.00009218082,0.0004899397],"genre_scores_gemma":[0.9978464,0.00005552659,0.001086664,0.00001567973,0.000003130386,0.000007589515,0.0002125205,0.00001422828,0.0007583037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007045191,"threshold_uncertainty_score":0.0025298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0123385085154543,"score_gpt":0.2360733189551562,"score_spread":0.2237348104397019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}