{"id":"W4221064798","doi":"10.1038/s41598-022-07513-9","title":"Structural modeling of human AKAP3 protein and in silico analysis of single nucleotide polymorphisms associated with sperm motility","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Genomics and Rare Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"In silico; Sperm; Biology; Sperm motility; Mutant; Genetics; Protein secondary structure; Male infertility; Motility; Infertility; Computational biology; Bioinformatics; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003034177,0.0008308154,0.0005973627,0.0005220857,0.0005842839,0.0004882949,0.0006577311,0.0006559479,0.002282546],"category_scores_gemma":[0.0005781204,0.0002901708,0.001033234,0.000540269,0.0001541566,0.0002585023,0.0002098537,0.0003821514,0.0005676305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005698337,"about_ca_system_score_gemma":0.0006592759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005354499,"about_ca_topic_score_gemma":0.004985228,"domain_scores_codex":[0.9998422,0.00005065561,0.00001147777,0.00004022021,0.00003324079,0.00002226865],"domain_scores_gemma":[0.999819,0.00008489237,0.00003179968,0.0000137782,0.00002838453,0.00002216092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.002216485,0.0005580044,0.03234836,0.0007001544,0.0004714381,0.002873121,0.000439215,0.7061245,0.2338901,0.00321208,0.002619303,0.01454714],"study_design_scores_gemma":[0.00007103324,0.0002360244,0.007659612,0.00002668333,0.000134091,0.00039301,0.0001105836,0.9720666,0.01673447,0.0007618065,0.001778111,0.00002799802],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805353,0.0004768747,0.01443745,0.0001283903,0.00002790895,0.00003426961,0.002257565,0.0005440562,0.001558125],"genre_scores_gemma":[0.9753528,0.0004197198,0.01694418,0.00003321231,0.000009589824,0.00006867949,0.006180901,0.0001578341,0.0008330477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005354499,"threshold_uncertainty_score":0.01064664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01296062220458256,"score_gpt":0.2267655877429413,"score_spread":0.2138049655383588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}