{"id":"W4221065411","doi":"10.1101/2022.03.30.486272","title":"Multi-omic profiling of the leukemic microenvironment shows bone marrow interstitial fluid is distinct from peripheral blood plasma","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Michael Smith Health Research BC; BC Children's Hospital; Children's Hospital Foundation","keywords":"Bone marrow; Interstitial fluid; Haematopoiesis; Extracellular fluid; Leukemia; Pathology; Biology; Cell biology; Chemistry; Medicine; Immunology; Stem cell; Extracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004187482,0.000558838,0.0007195864,0.002305068,0.0004579439,0.001609065,0.0002372375,0.0005855955,0.0008982778],"category_scores_gemma":[0.0004496619,0.0001866574,0.0006390041,0.001566727,0.0003685573,0.0005089153,0.0009128181,0.0007255749,0.000552972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002554293,"about_ca_system_score_gemma":0.0003491459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008190695,"about_ca_topic_score_gemma":0.001260867,"domain_scores_codex":[0.9995228,0.00005716351,0.00003177765,0.0001266364,0.0001748843,0.0000867096],"domain_scores_gemma":[0.9997674,0.00004608063,0.00006204144,0.00001864834,0.00006959858,0.00003619183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002983695,0.00005828182,0.0149102,0.0003595479,0.0001062309,0.0002564114,0.0001351034,0.0002048998,0.9715756,0.0001558596,0.0003304273,0.01160916],"study_design_scores_gemma":[0.00003551565,0.0007428204,0.5238149,0.0002355601,0.000557251,0.002618306,0.001394176,0.008135595,0.4312691,0.001415965,0.02964515,0.0001357306],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9361213,0.01430688,0.0296825,0.0005677894,0.0001404358,0.0002148337,0.01513201,0.0004712469,0.003363103],"genre_scores_gemma":[0.9251829,0.006356184,0.05005652,0.0007787124,0.000112901,0.0002684575,0.01389665,0.0002355095,0.003112183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002305068,"threshold_uncertainty_score":0.003005028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01656848419512737,"score_gpt":0.2362833416476481,"score_spread":0.2197148574525207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}