{"id":"W4221067578","doi":"10.4103/sjg.sjg_3_22","title":"Therapeutic drug monitoring for biological medications in inflammatory bowel disease","year":2022,"lang":"en","type":"review","venue":"Saudi Journal of Gastroenterology","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Medicine; Therapeutic drug monitoring; Inflammatory bowel disease; Drug; Intensive care medicine; Vedolizumab; Trough level; Disease; Immunogenicity; Pharmacology; Immunology; Internal medicine; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009441085,0.0007714789,0.001278725,0.003323729,0.0002567458,0.0008594159,0.0007749629,0.001182676,0.003378609],"category_scores_gemma":[0.001909425,0.0002204896,0.0008964087,0.0026876,0.0005818373,0.001204672,0.000587258,0.001562866,0.001345372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006046036,"about_ca_system_score_gemma":0.001276889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001444448,"about_ca_topic_score_gemma":0.002381544,"domain_scores_codex":[0.9993532,0.0001510255,0.0001458917,0.00006459253,0.0002583484,0.00002685723],"domain_scores_gemma":[0.9987643,0.0006973319,0.0002733874,0.00002724128,0.000200674,0.00003716729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006406622,0.00005565867,0.000446126,0.03534028,0.0001525237,0.0002308762,0.00006440886,0.0001537559,0.0005353576,0.001547634,0.01707604,0.9443333],"study_design_scores_gemma":[0.00004859631,0.0001462854,0.00361414,0.0245594,0.0004165157,0.004609635,0.0001060505,0.0001355699,0.0006011988,0.001535544,0.9641978,0.0000291677],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000779348,0.9989542,0.00006475234,0.0002027313,0.00009108114,0.000005842452,0.00001175265,0.000003695634,0.0005881145],"genre_scores_gemma":[0.001023226,0.9981351,0.0002282882,0.0002185748,0.0001121601,0.000009176252,0.0000189034,0.000001015802,0.0002534719],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003378609,"threshold_uncertainty_score":0.01130253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1322671585482503,"score_gpt":0.426788088600274,"score_spread":0.2945209300520237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}