{"id":"W4221067692","doi":"10.1101/2022.03.13.484113","title":"Effect of GDF15 on acetaminophen (APAP)-induced liver injury in mice","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"GDF15 and Related Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Natural Science Foundation of China","keywords":"GCLC; GCLM; Acetaminophen; Liver injury; GDF15; Glutathione; Pharmacology; Cysteine; Chemistry; Biology; Endocrinology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001551997,0.0007062509,0.001231317,0.0008383712,0.00008866682,0.00003136193,0.0004991178,0.0009939139,0.0002663561],"category_scores_gemma":[0.0005056006,0.0006438585,0.0003590126,0.0009076829,0.0001237591,0.00005949077,0.0006024324,0.002183658,0.00008041688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006491943,"about_ca_system_score_gemma":0.0006043055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001906478,"about_ca_topic_score_gemma":0.000001184302,"domain_scores_codex":[0.9962155,0.0005565035,0.000773363,0.001101432,0.0007229313,0.0006303308],"domain_scores_gemma":[0.9973227,0.0002162948,0.0006554446,0.001322721,0.0001858071,0.0002969865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001697558,0.0004467133,0.02154635,0.00211877,0.0004007784,0.0005613032,0.00002688564,0.00001992733,0.9726682,0.00004546062,0.0004424452,0.00002556282],"study_design_scores_gemma":[0.002709388,0.001920009,0.2070303,0.001700125,0.0005313677,7.695401e-8,0.000004500306,0.0001457672,0.7836947,2.484301e-7,0.00156079,0.0007027091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951827,0.0009245803,0.000002666512,0.0001725419,0.001501425,0.001754619,0.0001154644,0.0002029017,0.0001430789],"genre_scores_gemma":[0.9985876,0.0003470007,0.0002394832,0.0002081526,0.0002004483,0.0002308401,0.000001231891,0.0001570408,0.00002817309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1889735,"threshold_uncertainty_score":0.9996012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01049160415232582,"score_gpt":0.2407365837144061,"score_spread":0.2302449795620803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}