{"id":"W4221068906","doi":"10.1158/1538-7445.sabcs21-p5-16-10","title":"Abstract P5-16-10: RLY-2608: The first allosteric mutant- and isoform-selective inhibitor of PI3Kα, is efficacious as a single agent and drives regressions in combination with standard of care therapies in <i>PIK3CA</i> mutant breast cancer models","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Paraza Pharma (Canada)","funders":"","keywords":"Fulvestrant; PI3K/AKT/mTOR pathway; Allosteric regulation; Mutant; Pharmacology; Kinase; Cancer research; Estrogen receptor; Cancer; Chemistry; Breast cancer; Biology; Medicine; Receptor; Internal medicine; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004042654,0.0002225879,0.0005159195,0.0003839173,0.0002705154,0.00002476901,0.0001806145,0.00006624779,0.000206829],"category_scores_gemma":[0.00002510608,0.0001553499,0.00004276572,0.0009549862,0.0006754475,0.000204889,0.0002045821,0.0006250648,2.151109e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001623128,"about_ca_system_score_gemma":0.0006979418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005221758,"about_ca_topic_score_gemma":0.007807564,"domain_scores_codex":[0.99757,0.0001498357,0.0003783256,0.0004554105,0.0009973299,0.0004491028],"domain_scores_gemma":[0.9986358,0.0002244249,0.000192053,0.0003133837,0.0005364225,0.00009787112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"qualitative","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.06797569,0.001751857,0.06807985,0.002573179,0.0006977007,0.0002092533,0.3723898,0.005806835,0.2274325,0.0003475344,0.0002731843,0.2524626],"study_design_scores_gemma":[0.04963822,0.01900804,0.2893797,0.01278507,0.0002467805,0.0005486048,0.3012314,0.001324363,0.3110746,0.005431622,0.007750957,0.001580678],"study_design_candidate":"qualitative","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794878,0.01427604,0.00001346662,0.004168699,0.00003901502,0.001365851,0.0004775513,0.00001413345,0.0001574924],"genre_scores_gemma":[0.9970653,0.001874692,0.00003400876,0.0001157132,0.00003214385,0.0007574253,0.000009738374,0.00004780175,0.00006320005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2508819,"threshold_uncertainty_score":0.789377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03047427801557876,"score_gpt":0.3382603510103763,"score_spread":0.3077860729947975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}