{"id":"W4221068906","doi":"10.1158/1538-7445.sabcs21-p5-16-10","title":"Abstract P5-16-10: RLY-2608: The first allosteric mutant- and isoform-selective inhibitor of PI3Kα, is efficacious as a single agent and drives regressions in combination with standard of care therapies in <i>PIK3CA</i> mutant breast cancer models","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Paraza Pharma (Canada)","funders":"","keywords":"Fulvestrant; PI3K/AKT/mTOR pathway; Allosteric regulation; Mutant; Pharmacology; Kinase; Cancer research; Estrogen receptor; Cancer; Chemistry; Breast cancer; Biology; Medicine; Receptor; Internal medicine; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002030396,0.0007814584,0.0004390522,0.0003039272,0.0001766183,0.0004702848,0.000549689,0.0005275591,0.008209006],"category_scores_gemma":[0.0001012965,0.0002354405,0.0004185331,0.0002496114,0.0003137887,0.0003189699,0.0002109164,0.001905052,0.003096648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005147331,"about_ca_system_score_gemma":0.0007043983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009464659,"about_ca_topic_score_gemma":0.001462404,"domain_scores_codex":[0.9998798,0.00001017734,0.000008308441,0.0000316095,0.0000350968,0.00003501409],"domain_scores_gemma":[0.9999384,0.000003252297,0.00001189348,0.000006439504,0.000005507612,0.00003455503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004659686,0.001488639,0.0004010902,0.0004687972,0.00007190266,0.0002672538,0.00003693587,0.0009732833,0.9204301,0.001022845,0.009465788,0.06071376],"study_design_scores_gemma":[0.003706522,0.02010994,0.004583697,0.00008590858,0.0001937099,0.001720744,0.00004926066,0.003013875,0.8846151,0.0003907461,0.081475,0.00005555314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9061458,0.02513074,0.01152551,0.002055296,0.001313609,0.0009591277,0.01112771,0.003730155,0.03801216],"genre_scores_gemma":[0.9500856,0.007905918,0.004766951,0.0005001654,0.00009230146,0.0003158271,0.007377811,0.0001646979,0.02879062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008209006,"threshold_uncertainty_score":0.02746189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03047427801557876,"score_gpt":0.3382603510103763,"score_spread":0.3077860729947975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}