{"id":"W4221068958","doi":"10.3390/curroncol29030164","title":"Cost-Effectiveness of Brexucabtagene Autoleucel versus Best Supportive Care for the Treatment of Relapsed/Refractory Mantle Cell Lymphoma following Treatment with a Bruton’s Tyrosine Kinase Inhibitor in Canada","year":2022,"lang":"en","type":"article","venue":"Current Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; University of British Columbia; Université Laval; Gilead Sciences (Canada)","funders":"","keywords":"Mantle cell lymphoma; Medicine; Ibrutinib; Internal medicine; Oncology; Cost effectiveness; Quality-adjusted life year; Quality of life (healthcare); Lymphoma; Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002055124,0.0007895104,0.001251035,0.0009384539,0.0005596163,0.00188057,0.001356342,0.0008003192,0.003278566],"category_scores_gemma":[0.007059649,0.000408749,0.001804192,0.0009692846,0.0006353596,0.0006242832,0.0008949106,0.001058815,0.0001253511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0380861,"about_ca_system_score_gemma":0.02886565,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.8538924,"about_ca_topic_score_gemma":0.8447644,"domain_scores_codex":[0.9990392,0.0004239092,0.00003877481,0.00007446635,0.0001655338,0.0002580705],"domain_scores_gemma":[0.9982431,0.001012953,0.0001549556,0.00003015319,0.0002880938,0.0002707253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.008677507,0.0004264637,0.01468421,0.001070677,0.001394477,0.0003077476,0.0001082297,0.9102429,0.0007338323,0.006913309,0.003422137,0.05201852],"study_design_scores_gemma":[0.003893077,0.002354713,0.02370552,0.0007252976,0.003252321,0.0002646633,0.0005007771,0.9537309,0.001106834,0.004169032,0.006165985,0.0001308455],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9517732,0.01805102,0.004639978,0.003572363,0.0001090778,0.0009593663,0.005155708,0.0001098985,0.01562954],"genre_scores_gemma":[0.9941221,0.00215822,0.001333266,0.0001776138,0.000008618349,0.0000686466,0.0008142297,0.00001047722,0.001306773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1461076,"threshold_uncertainty_score":0.2939361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09165952177948525,"score_gpt":0.3858130364135706,"score_spread":0.2941535146340853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}