{"id":"W4221077169","doi":"10.1021/acs.orglett.2c00444","title":"Total Synthesis of (−)-3-Oxoisotaxodione","year":2022,"lang":"en","type":"article","venue":"Organic Letters","topic":"Marine Sponges and Natural Products","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Polyene; Total synthesis; Natural product; Enantioselective synthesis; Quinone methide; Bicyclic molecule; Stereochemistry; Substrate (aquarium); Combinatorial chemistry; Organic chemistry; Catalysis; Quinone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007147672,0.0003963348,0.0002714578,0.0002748367,0.0001678685,0.000228964,0.0001763622,0.0001145318,0.003981951],"category_scores_gemma":[0.00008145809,0.00008869662,0.0001591281,0.0002714358,0.0001398663,0.0002030114,0.0003422486,0.0003438278,0.001343039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002485334,"about_ca_system_score_gemma":0.0005356302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000581275,"about_ca_topic_score_gemma":0.001253081,"domain_scores_codex":[0.9999489,0.000003732235,0.000004894476,0.000011633,0.00001184109,0.00001906264],"domain_scores_gemma":[0.9999554,0.000003937877,0.000004333168,0.000006072776,0.000008732779,0.00002159744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009013922,0.00003093776,0.0001861508,0.0002908029,0.00001763875,0.0003279651,0.000126609,0.000729821,0.9700141,0.002491258,0.0002984396,0.02539597],"study_design_scores_gemma":[0.0000426287,0.0007441099,0.002014063,0.00004076746,0.00003942141,0.0006546406,0.00008327649,0.0004703819,0.9294499,0.001059181,0.06536201,0.00003957887],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8884634,0.00779756,0.04639568,0.0002621492,0.0003504573,0.0003641013,0.004649287,0.000541181,0.05117626],"genre_scores_gemma":[0.9627168,0.003749729,0.01335356,0.00006476504,0.00001992372,0.00009446579,0.0011776,0.00005503618,0.01876809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003981951,"threshold_uncertainty_score":0.01332092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003863552224306044,"score_gpt":0.1860721532305725,"score_spread":0.1822086010062664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}