{"id":"W4221077568","doi":"10.3390/cancers14061374","title":"Next Generation of Cancer Drug Repurposing: Therapeutic Combination of Aspirin and Oseltamivir Phosphate Potentiates Gemcitabine to Disable Key Survival Pathways Critical for Pancreatic Cancer Progression","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Gemcitabine; Pancreatic cancer; Clonogenic assay; Cancer research; Viability assay; Medicine; Cancer; Cytotoxicity; Apoptosis; Cancer cell; Pharmacology; Chemistry; Internal medicine; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003905452,0.000194369,0.0004184673,0.00009717794,0.000325771,0.00001599292,0.0001916327,0.00008283663,0.0004271342],"category_scores_gemma":[0.00005716242,0.0001896678,0.00008080841,0.000234904,0.0002653934,0.0001331689,0.0001296848,0.0001725567,0.000001287202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007101887,"about_ca_system_score_gemma":0.0003739115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001710198,"about_ca_topic_score_gemma":0.0002164648,"domain_scores_codex":[0.9985223,0.0001874723,0.0004391528,0.0003875217,0.0001119205,0.0003515976],"domain_scores_gemma":[0.9990884,0.0001624282,0.0002460306,0.0002469218,0.0002297512,0.00002644312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007092244,0.0001051421,0.006357369,0.0003668345,0.0002430993,6.311071e-7,0.001937572,0.002871094,0.938167,0.001940131,0.001495366,0.04580653],"study_design_scores_gemma":[0.003142904,0.0008472904,0.003826265,0.0003008039,0.0003676889,0.000003775675,0.001344016,0.0026625,0.9692071,0.0004756369,0.01739879,0.0004232036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9240546,0.07118175,0.0003073821,0.0004760373,0.002659011,0.0009677726,0.0002607126,0.00003052135,0.00006225217],"genre_scores_gemma":[0.9960853,0.001297602,0.0002049665,0.0001994283,0.00004543531,0.001396318,0.0001415486,0.00003840316,0.0005910076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07203073,"threshold_uncertainty_score":0.7734428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0429951206041,"score_gpt":0.3088651733980359,"score_spread":0.2658700527939359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}