{"id":"W4221077568","doi":"10.3390/cancers14061374","title":"Next Generation of Cancer Drug Repurposing: Therapeutic Combination of Aspirin and Oseltamivir Phosphate Potentiates Gemcitabine to Disable Key Survival Pathways Critical for Pancreatic Cancer Progression","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Gemcitabine; Pancreatic cancer; Clonogenic assay; Cancer research; Viability assay; Medicine; Cancer; Cytotoxicity; Apoptosis; Cancer cell; Pharmacology; Chemistry; Internal medicine; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000181742,0.0004574945,0.000421838,0.0004125338,0.000135231,0.0004073607,0.0002551372,0.0002923727,0.002701147],"category_scores_gemma":[0.0001018244,0.0001118906,0.0003149048,0.0001555997,0.0001498926,0.0002597017,0.0001859183,0.0005723447,0.000434138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002887793,"about_ca_system_score_gemma":0.0002487276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002148564,"about_ca_topic_score_gemma":0.0008352065,"domain_scores_codex":[0.9998975,0.00002202471,0.000006971715,0.00001933925,0.00003096303,0.00002326555],"domain_scores_gemma":[0.9999738,0.000003125035,0.000005506619,0.000004257191,0.000003996081,0.000009336493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009764711,0.0008326226,0.0008891782,0.0002533937,0.00005384032,0.0002877977,0.00004210688,0.0005534629,0.9153607,0.001316387,0.001217724,0.07821637],"study_design_scores_gemma":[0.0004745163,0.007098076,0.005100826,0.00003602932,0.0002239873,0.001338142,0.00003819952,0.003309693,0.9324314,0.000352881,0.0495743,0.00002195937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9545265,0.02153561,0.009898153,0.0009362528,0.0004854676,0.0004484514,0.0005653809,0.0002671699,0.01133706],"genre_scores_gemma":[0.9745388,0.00834801,0.008389683,0.0003006724,0.00008958446,0.0002330211,0.000610409,0.00001683181,0.007472917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002701147,"threshold_uncertainty_score":0.009036183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0429951206041,"score_gpt":0.3088651733980359,"score_spread":0.2658700527939359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}