{"id":"W4221081202","doi":"10.1016/j.joca.2022.02.150","title":"SINGLE NUCLEUS RNA SEQUENCING PROFILING IDENTIFIES DISTINCT CELLULAR POPULATIONS IN THE SYNOVIUM OF EARLY AND LATE STAGE RADIOGRAPHIC KNEE OA","year":2022,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Krembil Foundation; University of Toronto; University Health Network","funders":"","keywords":"Biology; Nucleus; Profiling (computer programming); RNA; Computational biology; Pathology; Medicine; Cell biology; Genetics; Gene; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002001846,0.000157912,0.0003007408,0.0007490516,0.0002812803,0.0006988148,0.0001371346,0.0003374557,0.001275636],"category_scores_gemma":[0.0003205115,0.0001876938,0.0002363606,0.0002961583,0.0003038986,0.000264478,0.0002408274,0.0002509173,0.0004333658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001866761,"about_ca_system_score_gemma":0.0001936767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001338491,"about_ca_topic_score_gemma":0.00373895,"domain_scores_codex":[0.9998061,0.00002359624,0.00001521773,0.00004848634,0.00005543645,0.00005112025],"domain_scores_gemma":[0.9998114,0.00004113737,0.00004284272,0.00001063514,0.00005458107,0.00003953023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003649669,0.000009170725,0.00677411,0.00005254467,0.00001300398,0.00005206278,0.0001000466,0.00002384283,0.990447,0.00005484884,0.00004079057,0.002067623],"study_design_scores_gemma":[0.00005044985,0.0007987352,0.7605616,0.0000557079,0.0001123917,0.0009628268,0.001736472,0.001668224,0.2304116,0.0003592722,0.003251167,0.00003150722],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939889,0.001873017,0.002275275,0.0000590293,0.00002461449,0.00001919769,0.0006843905,0.00002767722,0.00104779],"genre_scores_gemma":[0.9946626,0.0007149457,0.001545854,0.0001060202,0.00002257505,0.00004019489,0.0008216286,0.00002098478,0.002065344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001338491,"threshold_uncertainty_score":0.004267395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02517382967419014,"score_gpt":0.2383205037150485,"score_spread":0.2131466740408583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}