{"id":"W4221083544","doi":"10.1158/1538-7445.sabcs21-pd15-05","title":"Abstract PD15-05: Assessment of estrogen receptor (ESR1) mRNA expression for prediction of extended aromatase inhibitor benefit in HR-positive breast cancer using NRG Oncology/NSABP B-42","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Letrozole; Aromatase inhibitor; Medicine; Internal medicine; Tamoxifen; Oncology; Breast cancer; Clinical endpoint; Proportional hazards model; Cancer; Aromatase; Gynecology; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001171639,0.0002250403,0.00032301,0.0002562824,0.00009756969,0.0002950483,0.0002122024,0.0001649531,0.001180234],"category_scores_gemma":[0.001401776,0.0001044469,0.000229452,0.0002495942,0.0001862036,0.0001326088,0.0002067924,0.0002685399,0.0002449726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001747223,"about_ca_system_score_gemma":0.0002790273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004376514,"about_ca_topic_score_gemma":0.0006104393,"domain_scores_codex":[0.9995261,0.0002189775,0.00003282711,0.00009430519,0.00009970991,0.00002799968],"domain_scores_gemma":[0.9993092,0.000227901,0.0002367699,0.00006007883,0.00005859231,0.0001074089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008579792,0.0002780212,0.9702815,0.00003264415,0.0001677639,0.00007803839,0.00002932865,0.0006007324,0.00929255,0.00002606615,0.0001711031,0.01046239],"study_design_scores_gemma":[0.0003917363,0.004626922,0.9857038,0.000004801826,0.0001407707,0.0003488466,0.00003360795,0.002835529,0.005325082,0.0000551707,0.0005278715,0.000005931873],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991807,0.00007509589,0.0002539083,0.00001286002,0.00000220528,0.00002034756,0.0002540595,0.000005519917,0.0001951549],"genre_scores_gemma":[0.9990778,0.00001631189,0.0003904374,0.00001226452,0.000003713245,0.0000191321,0.00032482,0.000001739168,0.000153816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001180234,"threshold_uncertainty_score":0.00619626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03682718754772205,"score_gpt":0.4001597617387765,"score_spread":0.3633325741910544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}