{"id":"W4221087280","doi":"10.1261/rna.079104.122","title":"ZFC3H1 and U1-70K promote the nuclear retention of mRNAs with 5′ splice site motifs within nuclear speckles","year":2022,"lang":"en","type":"article","venue":"RNA","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; snRNP; RNA splicing; Nuclear export signal; Cell biology; Precursor mRNA; Cell nucleus; RNA; Molecular biology; Gene; Genetics; Nucleus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001501125,0.0003068469,0.0002791753,0.0002010599,0.00021928,0.0002540358,0.0002521971,0.0002450504,0.001033955],"category_scores_gemma":[0.0001479071,0.0001312714,0.0002321548,0.0001682761,0.0003638779,0.0001310755,0.0002854891,0.0004010085,0.0002844577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005012252,"about_ca_system_score_gemma":0.0003614182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00188564,"about_ca_topic_score_gemma":0.002625579,"domain_scores_codex":[0.9998672,0.000009936326,0.000008475307,0.00003598333,0.0000394036,0.00003892638],"domain_scores_gemma":[0.9998738,0.00001966501,0.00004011376,0.00001168706,0.000008284607,0.00004638187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001091177,0.00001984079,0.0002413162,0.00002638805,0.000003661824,0.00003511801,0.000009461885,0.00006618914,0.9974421,0.0001188115,0.00007587965,0.001852056],"study_design_scores_gemma":[0.00002382764,0.0001040809,0.006890404,0.000002558041,0.000006500727,0.0001510747,0.00001151562,0.0008239478,0.9900321,0.00004716168,0.001903399,0.000003494743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923844,0.001637602,0.003543678,0.0001461853,0.00003128297,0.00002005031,0.0003234202,0.0002686745,0.0016447],"genre_scores_gemma":[0.9946334,0.0003112086,0.002336693,0.00007395725,0.00001083481,0.00002113101,0.0004133553,0.00003737783,0.002161999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00188564,"threshold_uncertainty_score":0.003749371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008214130258449732,"score_gpt":0.2162918613580745,"score_spread":0.2080777310996247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}