{"id":"W4221087280","doi":"10.1261/rna.079104.122","title":"ZFC3H1 and U1-70K promote the nuclear retention of mRNAs with 5′ splice site motifs within nuclear speckles","year":2022,"lang":"en","type":"article","venue":"RNA","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; snRNP; RNA splicing; Nuclear export signal; Cell biology; Precursor mRNA; Cell nucleus; RNA; Molecular biology; Gene; Genetics; Nucleus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003680942,0.00008464729,0.00009160516,0.00002550063,0.0002367276,0.00002158189,0.0001666846,0.00003324561,0.00005832649],"category_scores_gemma":[0.0000317051,0.00005986571,0.0000386798,0.00008971545,0.00009979048,0.000005092611,0.0002307617,0.0001514287,0.000004608565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001439199,"about_ca_system_score_gemma":0.00002994603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001122041,"about_ca_topic_score_gemma":0.00003114059,"domain_scores_codex":[0.9991603,0.00007484692,0.000120549,0.0002180603,0.0002606137,0.0001656572],"domain_scores_gemma":[0.9995281,0.000005221588,0.00008325648,0.0002764699,0.00005224323,0.00005468967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002481962,0.00003188438,0.0004554223,0.00002510364,0.00004189811,0.000007466258,0.000321872,0.00008526927,0.996281,0.0003035665,0.0009409679,0.001257307],"study_design_scores_gemma":[0.005227766,0.01179849,0.04522042,0.0002320996,0.0002376143,0.0008261382,0.01302348,0.02182381,0.5856863,0.0006667802,0.313731,0.001526109],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979755,0.0002513708,0.00001836852,0.0004395909,0.00002378542,0.0001784286,0.00001529563,0.0000086007,0.001089096],"genre_scores_gemma":[0.9979386,0.0001068897,0.00043144,0.0001039162,0.00005458989,0.000005414186,0.00001424625,0.00002472367,0.001320207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4105948,"threshold_uncertainty_score":0.2441253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008214130258449732,"score_gpt":0.2162918613580745,"score_spread":0.2080777310996247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}