{"id":"W4221087847","doi":"10.1158/1538-7445.sabcs21-ot1-06-01","title":"Abstract OT1-06-01: A randomised trial comparing continuation or de-escalation of bone modifying agents (BMA) in patients treated for over 2 years for bone metastases from either breast or castration-resistant prostate cancer (REaCT-HOLD BMA)","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; McMaster University; University of Ottawa","funders":"","keywords":"Medicine; Breast cancer; Clinical endpoint; Denosumab; Randomized controlled trial; Internal medicine; Oncology; Clinical trial; Cancer; Surgery; Osteoporosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003459014,0.00230583,0.003659589,0.0005535801,0.0006110549,0.001814111,0.00145153,0.003345757,0.01976519],"category_scores_gemma":[0.004867519,0.0009009629,0.003551073,0.0005786287,0.001687143,0.001774602,0.0009475477,0.004876317,0.002527364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001015018,"about_ca_system_score_gemma":0.001763084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001509082,"about_ca_topic_score_gemma":0.002559681,"domain_scores_codex":[0.9980994,0.001224876,0.0001381259,0.0002507078,0.00009949174,0.0001874537],"domain_scores_gemma":[0.9971476,0.0009559975,0.0006735218,0.0001975284,0.0001873771,0.000837958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.988876,0.003394452,0.0001350776,0.0008315432,0.0005210192,0.00002152822,0.0000439476,0.0001383417,0.000881299,0.000109026,0.000414468,0.004633168],"study_design_scores_gemma":[0.9629827,0.03588554,0.0002838575,0.00004234592,0.0002623281,0.00001073816,0.00001558088,0.00009633995,0.00006261438,0.00006623729,0.0002844467,0.000007355762],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9533679,0.007748046,0.001220202,0.002441492,0.002786207,0.02307673,0.003278759,0.0002596083,0.005820955],"genre_scores_gemma":[0.953612,0.003568345,0.00405534,0.003355118,0.001509242,0.02148356,0.002605863,0.00004922879,0.00976139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01976519,"threshold_uncertainty_score":0.06612116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1642292200788514,"score_gpt":0.4298036303402548,"score_spread":0.2655744102614034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}