{"id":"W4221088064","doi":"10.3389/fgene.2022.848646","title":"Identification of Common and Distinct Pathways in Inflammatory Bowel Disease and Colorectal Cancer: A Hypothesis Based on Weighted Gene Co-Expression Network Analysis","year":2022,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Inflammatory bowel disease; Ulcerative colitis; Colorectal cancer; Gene; Disease; Biology; Cancer; Gene expression; Gene ontology; Gene expression profiling; Gene regulatory network; Computational biology; Genetics; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006543619,0.0003572706,0.0004728285,0.001479364,0.0003226007,0.0005705354,0.0003822407,0.0002030555,0.0009062073],"category_scores_gemma":[0.001535333,0.0001537458,0.0008296347,0.001653083,0.0003899561,0.000594453,0.0005784632,0.000271051,0.0001138085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003635303,"about_ca_system_score_gemma":0.0005151638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001985187,"about_ca_topic_score_gemma":0.002291904,"domain_scores_codex":[0.9996215,0.0001218717,0.00001560722,0.000130946,0.00005262151,0.00005734848],"domain_scores_gemma":[0.999441,0.0002446556,0.0001504397,0.00005200531,0.00005649647,0.00005536548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001819002,0.0003678536,0.5043988,0.001041293,0.002807541,0.001328325,0.0006532227,0.1958838,0.1376298,0.03095791,0.001712594,0.1213999],"study_design_scores_gemma":[0.00006708943,0.0002825926,0.3207182,0.00006327112,0.0008345534,0.0009855203,0.0003450792,0.6192558,0.008350665,0.04615103,0.002885422,0.00006077996],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8793371,0.001513942,0.1160799,0.0003458222,0.00001633188,0.00007432422,0.001248427,0.0001707459,0.001213305],"genre_scores_gemma":[0.9796017,0.0005492413,0.01819943,0.00004619462,0.00001117822,0.00007156537,0.001192756,0.00001568087,0.0003121262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001985187,"threshold_uncertainty_score":0.003947258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00509944153931777,"score_gpt":0.2107910377331224,"score_spread":0.2056915961938046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}