{"id":"W4221089965","doi":"10.1038/s41586-022-04537-z","title":"Targeting Xist with compounds that disrupt RNA structure and X inactivation","year":2022,"lang":"en","type":"article","venue":"Nature","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":129,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Lethbridge","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Wellcome Trust; National Institute of Mental Health; Howard Hughes Medical Institute","keywords":"XIST; RNA; Epigenetics; Computational biology; Small molecule; X-inactivation; Nucleic acid structure; Biology; Histone; Cell biology; Non-coding RNA; RNA-binding protein; Chemical space; Genetics; Chemistry; Drug discovery; X chromosome; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003925921,0.00006732052,0.00004880402,0.00001661043,0.0002192331,0.00002058171,0.00007377732,0.0001602265,0.00003067346],"category_scores_gemma":[0.000006726634,0.00005528852,0.00001210583,0.00006655197,0.00002611875,0.000003363821,0.00005707311,0.0004758812,1.032648e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000194796,"about_ca_system_score_gemma":0.00002602431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006688055,"about_ca_topic_score_gemma":0.000006489016,"domain_scores_codex":[0.9995698,0.00002162609,0.00004280948,0.0001785329,0.0001070066,0.00008026465],"domain_scores_gemma":[0.9997742,0.000003046757,0.0000452805,0.0001263948,0.00002934773,0.00002170705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000117415,0.00002131321,0.01224607,0.00001169332,0.00003207368,0.000001881693,0.00008958597,0.0003113833,0.9759457,0.0004545466,0.008619906,0.002148485],"study_design_scores_gemma":[0.0015189,0.0004765533,0.08332416,0.00001163279,0.00003874346,0.0001025335,0.001559211,0.0003361443,0.290883,0.0004090947,0.6207684,0.0005716252],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967346,0.001816842,0.0001839721,0.0005180648,0.00008253876,0.00007996554,0.00005691152,0.000006825162,0.0005203419],"genre_scores_gemma":[0.9982978,0.00003484532,0.0003261517,0.0004938576,0.0001000767,0.00001565874,0.0003841691,0.00001058737,0.0003368357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6850626,"threshold_uncertainty_score":0.22546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005070391603242175,"score_gpt":0.2345769657958009,"score_spread":0.2295065741925587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}