{"id":"W4221091248","doi":"10.1093/brain/awac107","title":"Progression of cerebral white matter hyperintensities is related to leucocyte gene expression","year":2022,"lang":"en","type":"article","venue":"Brain","topic":"Neurological Disease Mechanisms and Treatments","field":"Neuroscience","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute on Aging; Canadian Institutes of Health Research; National Institutes of Health; University Hospital Foundation; Canada Research Chairs; Heart and Stroke Foundation of Canada","keywords":"Hyperintensity; White matter; Medicine; Interquartile range; Pathology; Quartile; Internal medicine; Cardiology; Magnetic resonance imaging; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00006219596,0.000113552,0.000136695,0.00006829211,0.0001850712,0.00001523679,0.0001718118,0.00002558714,0.002920592],"category_scores_gemma":[0.00004796994,0.00008847033,0.00007021271,0.0001827557,0.00003180341,0.00005578772,0.0003900371,0.0001001628,0.0001366601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001953278,"about_ca_system_score_gemma":0.00001162583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002796017,"about_ca_topic_score_gemma":8.60077e-8,"domain_scores_codex":[0.9987618,0.0001707891,0.0001685346,0.0003785484,0.0003148518,0.0002054929],"domain_scores_gemma":[0.9995435,0.00004479299,0.00006776687,0.00023481,0.00001341385,0.00009564514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002152703,0.0001889347,0.004644633,0.000007662123,0.000002565494,0.0001432442,0.0003750325,0.00005237765,0.9875007,0.0002413247,0.005975556,0.0006527501],"study_design_scores_gemma":[0.0005388733,0.0005412071,0.01521773,0.00001330651,0.000006223025,0.00004465483,0.00006348359,0.0001171476,0.9798544,0.001418143,0.002058571,0.0001262855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947817,0.00001369814,0.00003217295,0.003477146,0.0001728285,0.0002935673,0.0001036053,0.00005609489,0.001069172],"genre_scores_gemma":[0.9853156,8.333528e-7,0.000401827,0.01077965,0.000007264301,0.00008552163,0.000005524078,0.00001725791,0.003386485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0105731,"threshold_uncertainty_score":0.9979908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02292085758714801,"score_gpt":0.2669621037592208,"score_spread":0.2440412461720728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}