{"id":"W4221095058","doi":"10.3389/fendo.2022.855082","title":"Effect of Recombinant Gonadotropin on Testicular Function and Testicular Sperm Extraction in Five Cases of NR0B1 (DAX1) Pathogenic Variants","year":2022,"lang":"en","type":"article","venue":"Frontiers in Endocrinology","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McGill University","keywords":"Spermatogenesis; Gonadotropin; Azoospermia; Hypogonadotropic hypogonadism; Human chorionic gonadotropin; Internal medicine; Endocrinology; Testicular sperm extraction; Semen analysis; Biology; Sperm; Medicine; Andrology; Infertility; Hormone; Pregnancy; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002929748,0.0004243232,0.00040351,0.0007874453,0.0004809898,0.000346478,0.0002909764,0.0004318293,0.0006451891],"category_scores_gemma":[0.001235754,0.000258669,0.0004295509,0.0004007159,0.0005097774,0.0002073553,0.0003066538,0.0003369555,0.00008628117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003946089,"about_ca_system_score_gemma":0.0002607584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00160211,"about_ca_topic_score_gemma":0.001375129,"domain_scores_codex":[0.9996653,0.00006614646,0.00004729258,0.00009021632,0.00006611946,0.0000649167],"domain_scores_gemma":[0.9994234,0.0001710139,0.0001272553,0.00004396751,0.00003825753,0.0001962258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"case_report","study_design_scores_codex":[0.0006855771,0.0001862457,0.7897872,0.00004748537,0.00007252347,0.1810742,0.0008162109,0.0003102421,0.01972184,0.0001008628,0.0001012583,0.00709638],"study_design_scores_gemma":[0.00006095168,0.002534866,0.6495406,0.00001142495,0.00009200269,0.3368052,0.0005229767,0.0008291606,0.008797809,0.0000776432,0.0007050632,0.00002231667],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994174,0.0002151543,0.00009790096,0.00002126991,0.000005118892,0.000006314397,0.0000246346,0.000005235787,0.0002069366],"genre_scores_gemma":[0.9997123,0.00004660479,0.0001373206,0.0000185432,0.000008501564,0.000002226664,0.00003106823,0.000002124457,0.00004138445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00160211,"threshold_uncertainty_score":0.00318557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006603426532764896,"score_gpt":0.247086049339353,"score_spread":0.2404826228065881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}