{"id":"W4221097587","doi":"10.3390/curroncol29040176","title":"Ibrutinib in c-MYC and HER2 Amplified Oesophagogastric Carcinoma: Results of the Proof-of-Concept iMYC Study","year":2022,"lang":"en","type":"article","venue":"Current Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Ibrutinib; Neutropenia; Internal medicine; Clinical endpoint; Gastroenterology; Adverse effect; Oncology; Cancer; Chemotherapy; Leukemia; Clinical trial; Chronic lymphocytic leukemia","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002569117,0.0007929754,0.001324291,0.0001918807,0.0002004604,0.001228046,0.0006507582,0.0008806784,0.001485434],"category_scores_gemma":[0.0007500559,0.0001644418,0.000756453,0.0003104234,0.0003695326,0.0004743261,0.0003601302,0.002133658,0.0004417732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008057043,"about_ca_system_score_gemma":0.0008606813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007705436,"about_ca_topic_score_gemma":0.001051322,"domain_scores_codex":[0.9994857,0.0001944174,0.00002705345,0.00005540187,0.0001128354,0.0001245517],"domain_scores_gemma":[0.9995117,0.00008510424,0.00009964763,0.00003848238,0.00008606973,0.0001790426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.0859089,0.02847419,0.00994052,0.003855827,0.002397261,0.001999806,0.0007096955,0.01109888,0.5605516,0.001380375,0.01875773,0.2749252],"study_design_scores_gemma":[0.1036994,0.4659527,0.06277961,0.0008129787,0.004489712,0.007152429,0.0005500836,0.01411035,0.2166033,0.000835458,0.1228464,0.0001676378],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9568766,0.03392164,0.002211119,0.0009741553,0.0001865681,0.0007924002,0.001625851,0.0001064728,0.003305153],"genre_scores_gemma":[0.9688239,0.01801328,0.003233705,0.001355167,0.0001641988,0.000648909,0.004585573,0.0000768333,0.003098301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002569117,"threshold_uncertainty_score":0.013587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1077695695726028,"score_gpt":0.4049106857030513,"score_spread":0.2971411161304485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}