{"id":"W4221105120","doi":"10.1200/jco.21.02678","title":"Children's Oncology Group Trial AALL1231: A Phase III Clinical Trial Testing Bortezomib in Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia and Lymphoma","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Clinical Evaluative Sciences; SickKids Foundation; Hospital for Sick Children; Stollery Children's Hospital; University of Alberta","funders":"National Cancer Institute","keywords":"Medicine; Bortezomib; Internal medicine; Regimen; Lymphoblastic lymphoma; Prednisone; Proteasome inhibitor; Clinical trial; Lymphoma; Oncology; Multiple myeloma; Dexamethasone; Surgery; Gastroenterology; Immunology; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0221364,0.0005675631,0.005623821,0.0008122415,0.0002940725,0.00005008091,0.0009501333,0.001348785,0.0002921361],"category_scores_gemma":[0.03389511,0.000474636,0.001260389,0.001052764,0.001119706,0.0002702294,0.001033559,0.004184312,0.00002458195],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.006306678,"about_ca_system_score_gemma":0.03653642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003242562,"about_ca_topic_score_gemma":0.00007393619,"domain_scores_codex":[0.9800156,0.005500831,0.01039749,0.001105999,0.00173012,0.001249941],"domain_scores_gemma":[0.9479973,0.04343484,0.005522521,0.0006690973,0.0005554103,0.001820874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7079822,0.01885342,0.008831285,0.00002110421,0.0008316466,0.01694177,0.0001405775,0.00004191853,0.0001492571,0.00002872911,0.008394975,0.2377831],"study_design_scores_gemma":[0.752158,0.2002954,0.01797916,0.00006958628,0.001290474,0.004509014,0.00023406,0.003041687,0.000007251478,0.0001475225,0.01994366,0.0003241137],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867221,0.0003728116,0.0002615196,0.002271634,0.005775793,0.002623276,0.00003307701,0.00004585021,0.001893951],"genre_scores_gemma":[0.9787162,0.0009804373,0.006273844,0.004070948,0.009382611,0.0001696797,0.00003593227,0.00009410969,0.0002762294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.237459,"threshold_uncertainty_score":0.9999477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1056531384057165,"score_gpt":0.4566537923573419,"score_spread":0.3510006539516254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}