{"id":"W4221105522","doi":"10.1158/1538-7445.sabcs21-ot2-11-09","title":"Abstract OT2-11-09: Lidera breast cancer: A phase III adjuvant study of giredestrant (GDC-9545) vs physician’s choice of endocrine therapy (ET) in patients (pts) with estrogen receptor-positive, HER2-negative early breast cancer (ER+/HER2- EBC)","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Letrozole; Tamoxifen; Anastrozole; Tolerability; Internal medicine; Fulvestrant; Breast cancer; Oncology; Estrogen receptor; Cancer; Adverse effect","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001442429,0.001505361,0.002040127,0.0004696267,0.0003324714,0.001096965,0.001040235,0.001369985,0.009145281],"category_scores_gemma":[0.0009145056,0.0006519572,0.001613898,0.000410494,0.001204436,0.0008879302,0.0003740111,0.00459045,0.001732503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009161247,"about_ca_system_score_gemma":0.001557932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00160631,"about_ca_topic_score_gemma":0.004262293,"domain_scores_codex":[0.9996173,0.0001831341,0.00001376586,0.0000636027,0.00003481659,0.00008729098],"domain_scores_gemma":[0.9993686,0.0001047677,0.00009076827,0.0000549536,0.00003682095,0.0003440406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8620393,0.07589971,0.001588215,0.0007897174,0.000866143,0.00007362414,0.0001185331,0.00190618,0.01307727,0.0002750366,0.003289316,0.04007702],"study_design_scores_gemma":[0.5966866,0.3954495,0.003162852,0.00003661551,0.0003701021,0.00006871383,0.00004953243,0.0009748339,0.0013188,0.0001731454,0.001687682,0.00002160931],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855952,0.001688106,0.0005995547,0.0006023422,0.0003235762,0.004923212,0.002251769,0.000218026,0.003798224],"genre_scores_gemma":[0.9742846,0.002273835,0.002347934,0.001455355,0.0003299062,0.005892867,0.00377339,0.00007090707,0.009571222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009145281,"threshold_uncertainty_score":0.03059405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0176347581674941,"score_gpt":0.3443360846957387,"score_spread":0.3267013265282446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}