{"id":"W4221106600","doi":"10.1371/journal.pbio.3001578","title":"A light-inducible protein clustering system for in vivo analysis of α-synuclein aggregation in Parkinson disease","year":2022,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital; Université Laval; University of Victoria; Centre hospitalier universitaire de Québec","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Fondation CHU de Québec; Parkinson Society Canada; Banting Research Foundation; Canada Research Chairs; McGill University","keywords":"Biology; Parkinson's disease; Neurodegeneration; Protein aggregation; Alpha-synuclein; Synuclein; In vivo; Neuroscience; Synucleinopathies; Disease; Lewy body; Cell biology; Pathology; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005223756,0.0006000806,0.0003206453,0.0006721609,0.0004371735,0.0003888117,0.0005710397,0.0006285725,0.001429216],"category_scores_gemma":[0.000227756,0.0003749238,0.0003197256,0.0003864452,0.000353414,0.0003906562,0.0005168422,0.000940925,0.001131768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000536178,"about_ca_system_score_gemma":0.0004460019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007575676,"about_ca_topic_score_gemma":0.001602428,"domain_scores_codex":[0.9996067,0.00009537748,0.00004072711,0.0001101015,0.00008954674,0.00005757752],"domain_scores_gemma":[0.999665,0.00006314868,0.0000820303,0.00007285989,0.00004547874,0.00007144459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000294279,0.00001525967,0.00002423292,0.00001365917,0.000001555752,0.00001509614,0.000009225075,0.00003219217,0.9992686,0.00008534147,0.00002864211,0.0004767713],"study_design_scores_gemma":[0.00001985582,0.0001370448,0.00090059,0.000009434075,0.000009727132,0.000206042,0.00001011378,0.001752129,0.9940818,0.00006733141,0.002797082,0.000008814969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6168544,0.002676005,0.3678596,0.0006100384,0.0001822704,0.0008776422,0.002341556,0.00331265,0.005285854],"genre_scores_gemma":[0.7295141,0.002475267,0.2525745,0.000264475,0.00003955884,0.00122605,0.004230434,0.0007561516,0.00891945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001429216,"threshold_uncertainty_score":0.004781246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02615839651700209,"score_gpt":0.2675166292940763,"score_spread":0.2413582327770742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}