{"id":"W4221108062","doi":"10.1101/2022.03.23.484325","title":"SPACA6 structure reveals a conserved superfamily of gamete fusion-associated proteins","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Argonne National Laboratory; National Institute of General Medical Sciences; Canadian Institutes of Health Research; Office of Science; National Institutes of Health; U.S. Department of Energy","keywords":"Gamete; Fusion protein; Biology; SUPERFAMILY; Immunoglobulin superfamily; Protein Data Bank (RCSB PDB); Protein domain; Conserved sequence; Protein structure; Proteome; Protein family; Genetics; Cell biology; Computational biology; Peptide sequence; Sperm; Biochemistry; Receptor; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001087926,0.0003216983,0.000318608,0.000362546,0.000277953,0.0002355478,0.0002323399,0.0003337945,0.001893844],"category_scores_gemma":[0.0001396848,0.00009166962,0.000350664,0.0003727691,0.0001875378,0.0002220343,0.0002178757,0.0003753141,0.0005759078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002495547,"about_ca_system_score_gemma":0.0002118874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006325494,"about_ca_topic_score_gemma":0.0004277395,"domain_scores_codex":[0.9999361,0.00000600459,0.000003550226,0.00001958873,0.00002451322,0.00001018149],"domain_scores_gemma":[0.9998679,0.000008168473,0.00003221755,0.00000861181,0.00002142659,0.00006165537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009093286,0.0001283056,0.02212584,0.0003090859,0.00006350278,0.002878334,0.0002813449,0.001447581,0.9560247,0.001260797,0.002794715,0.01177656],"study_design_scores_gemma":[0.0002307957,0.002221981,0.3944614,0.0001368126,0.0001821402,0.02444519,0.001166047,0.05599277,0.4466369,0.003148512,0.07121984,0.0001576985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931496,0.001887803,0.002126201,0.0002300819,0.00005472111,0.00001548386,0.0009880201,0.0001906268,0.001357435],"genre_scores_gemma":[0.9911447,0.0005634979,0.003226988,0.0001066838,0.00002737503,0.000008006362,0.00325231,0.00001693215,0.001653454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001893844,"threshold_uncertainty_score":0.006335557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01329699685531186,"score_gpt":0.2120852021490914,"score_spread":0.1987882052937795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}