{"id":"W4221108062","doi":"10.1101/2022.03.23.484325","title":"SPACA6 structure reveals a conserved superfamily of gamete fusion-associated proteins","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Argonne National Laboratory; National Institute of General Medical Sciences; Canadian Institutes of Health Research; Office of Science; National Institutes of Health; U.S. Department of Energy","keywords":"Gamete; Fusion protein; Biology; SUPERFAMILY; Immunoglobulin superfamily; Protein Data Bank (RCSB PDB); Protein domain; Conserved sequence; Protein structure; Proteome; Protein family; Genetics; Cell biology; Computational biology; Peptide sequence; Sperm; Biochemistry; Receptor; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001089926,0.0006923085,0.001073681,0.0003246036,0.0003233996,0.0001656558,0.0009395322,0.0007572424,0.002293499],"category_scores_gemma":[0.0007861698,0.0006948158,0.0002620226,0.0007433509,0.0002246456,0.0001793134,0.001039692,0.001133941,0.00002635463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003689882,"about_ca_system_score_gemma":0.001001736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003544797,"about_ca_topic_score_gemma":0.00001986552,"domain_scores_codex":[0.9955964,0.000578921,0.0009726115,0.001263884,0.0008995869,0.0006885654],"domain_scores_gemma":[0.9961209,0.0001273939,0.001148547,0.001663892,0.0007027113,0.0002366071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008437433,0.00008068596,0.00647404,0.0004375812,0.00009380378,0.00002845388,0.000025471,0.000128391,0.9912931,0.00018769,0.001165948,4.5462e-7],"study_design_scores_gemma":[0.0006705955,0.0001725944,0.1042926,0.0003417949,0.0001821202,3.0718e-8,0.00001016734,0.0000434487,0.8921292,0.00003373592,0.001340379,0.0007834028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991551,0.0007067376,0.0001720594,0.0001096127,0.002949638,0.001373994,0.002687283,0.0004253951,0.00002432656],"genre_scores_gemma":[0.9950289,0.00006498401,0.003945709,0.0002687463,0.000315946,0.0002036613,0.000003367166,0.0001402871,0.00002844053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09916395,"threshold_uncertainty_score":0.9995503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01329699685531186,"score_gpt":0.2120852021490914,"score_spread":0.1987882052937795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}