{"id":"W4221109209","doi":"10.1016/j.tox.2022.153153","title":"Cadmium acute exposure induces metabolic and transcriptomic perturbations in human mature adipocytes","year":2022,"lang":"en","type":"article","venue":"Toxicology","topic":"Heavy Metal Exposure and Toxicity","field":"Environmental Science","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Université de Genève; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Adipose tissue; Cadmium; Homeostasis; Endocrinology; Internal medicine; Chemistry; Paracrine signalling; Transcriptome; Glucose homeostasis; Biology; Obesity; Insulin resistance; Gene expression; Biochemistry; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003010805,0.0001351029,0.0002401152,0.00008481203,0.0003156965,0.00001482626,0.0002124233,0.0001049353,0.00457172],"category_scores_gemma":[0.00001617326,0.0001305518,0.00004479809,0.0002880656,0.0001559163,0.0001429998,0.0001765997,0.0004206708,0.00003152676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008655064,"about_ca_system_score_gemma":0.00001866381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001963302,"about_ca_topic_score_gemma":0.001206486,"domain_scores_codex":[0.9987168,0.0002614928,0.0002246736,0.0003259236,0.0001663298,0.0003048115],"domain_scores_gemma":[0.9996403,0.00004380335,0.00005022345,0.0001691005,0.000002416637,0.00009419666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00003041807,0.0002327834,0.02351295,0.00000393738,0.00003813472,0.00005303539,0.002603472,0.0001198816,0.9678714,0.0021582,0.001036352,0.00233948],"study_design_scores_gemma":[0.001214811,0.0007399024,0.8586468,0.000002226837,0.0000952671,0.0001771756,0.0004879603,0.00006384859,0.03526248,0.00270168,0.1001933,0.0004144978],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994225,0.0005903507,0.000008973827,0.001089865,0.0001713255,0.0002258809,0.00003896162,0.00003502151,0.00361458],"genre_scores_gemma":[0.9970022,0.00002839713,0.0001941425,0.001238102,0.00003093575,0.0001195791,0.00001449038,0.00001289857,0.001359266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9326088,"threshold_uncertainty_score":0.9963382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01292057993842901,"score_gpt":0.2492533563701517,"score_spread":0.2363327764317227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}