{"id":"W4221109209","doi":"10.1016/j.tox.2022.153153","title":"Cadmium acute exposure induces metabolic and transcriptomic perturbations in human mature adipocytes","year":2022,"lang":"en","type":"article","venue":"Toxicology","topic":"Heavy Metal Exposure and Toxicity","field":"Environmental Science","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Université de Genève; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Adipose tissue; Cadmium; Homeostasis; Endocrinology; Internal medicine; Chemistry; Paracrine signalling; Transcriptome; Glucose homeostasis; Biology; Obesity; Insulin resistance; Gene expression; Biochemistry; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001013142,0.0001771886,0.0002596353,0.0002445716,0.0002395306,0.00033701,0.00007523615,0.0002447592,0.001127765],"category_scores_gemma":[0.00009300844,0.0001393677,0.000394598,0.0003175375,0.0001874255,0.00009048811,0.0003184252,0.0003978391,0.0002293221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001427348,"about_ca_system_score_gemma":0.0001770734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007044812,"about_ca_topic_score_gemma":0.001337134,"domain_scores_codex":[0.9998651,0.00001464083,0.00001050595,0.00005098688,0.00003359755,0.0000251995],"domain_scores_gemma":[0.9999454,0.00001289455,0.00001082738,0.000007570629,0.00001349768,0.000009804599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004571175,0.00003514717,0.003353632,0.00006993524,0.00002737209,0.0001551858,0.00007382126,0.00008409654,0.994059,0.00003203386,0.00009231821,0.001560534],"study_design_scores_gemma":[0.0001017776,0.001583843,0.3507562,0.00004366974,0.0001834937,0.001180398,0.000983382,0.001234782,0.6343631,0.0004622751,0.009067067,0.00004012646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991474,0.002770021,0.002280376,0.0001467882,0.00006758827,0.00003779164,0.002118289,0.00003878663,0.001066388],"genre_scores_gemma":[0.9907431,0.00173788,0.001738085,0.0002750119,0.00002232257,0.0001125521,0.002427126,0.00001663035,0.002927226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001127765,"threshold_uncertainty_score":0.003772795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01292057993842901,"score_gpt":0.2492533563701517,"score_spread":0.2363327764317227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}