{"id":"W4221112390","doi":"10.1136/jitc-2021-004241","title":"MER4 endogenous retrovirus correlated with better efficacy of anti-PD1/PD-L1 therapy in non-small cell lung cancer","year":2022,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Endogenous retrovirus; Medicine; Lung cancer; Oncology; Clinical endpoint; Transcriptome; Proportional hazards model; Internal medicine; Cancer; Gene expression; Immunology; Gene; Biology; Randomized controlled trial; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007270371,0.0002702103,0.0003931475,0.0003421548,0.000168664,0.000612252,0.0001701618,0.0002927378,0.001732667],"category_scores_gemma":[0.001150559,0.0001251642,0.0004575457,0.0003029104,0.0002716848,0.0002524708,0.0002268121,0.0005216425,0.000217995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003133209,"about_ca_system_score_gemma":0.0001638278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002527367,"about_ca_topic_score_gemma":0.0002686826,"domain_scores_codex":[0.9996922,0.00007090757,0.00002803533,0.00009852356,0.00006416599,0.00004625799],"domain_scores_gemma":[0.999208,0.0002447939,0.0003169213,0.00007101017,0.00009707096,0.00006217354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005635251,0.0002823009,0.8134184,0.0001334613,0.0003148883,0.0003896026,0.0001027057,0.004523918,0.1513418,0.0001619889,0.0003672153,0.02332851],"study_design_scores_gemma":[0.00009817937,0.002691918,0.9046556,0.00002420913,0.0003809998,0.001755647,0.0001894422,0.02103236,0.06656554,0.0004584013,0.002119096,0.00002861491],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987489,0.0002286632,0.0005561013,0.00001726615,0.000004242502,0.000006833929,0.0002212738,0.00001154996,0.000205138],"genre_scores_gemma":[0.9987515,0.00005019901,0.0003583117,0.00001677128,0.0000054609,0.00000907313,0.0006131206,0.000006049821,0.0001894621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001732667,"threshold_uncertainty_score":0.005796373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01871910087723406,"score_gpt":0.2492211519742953,"score_spread":0.2305020510970613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}