{"id":"W4221114436","doi":"10.1101/2022.03.30.486436","title":"Obligate sexual reproduction of a homothallic fungus closely related to the <i>Cryptococcus</i> pathogenic species complex","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Yeasts and Rust Fungi Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Human Genome Research Institute; National Institutes of Health; Deutsche Forschungsgemeinschaft; North Carolina State University; National Institute of Allergy and Infectious Diseases; Broad Institute; Canadian Institute for Advanced Research","keywords":"Biology; Homothallism; Mating type; Heterothallic; Sexual reproduction; Obligate; Cryptococcus neoformans; Genetics; Cryptococcus; Cryptococcus gattii; Synteny; Basidium; Evolutionary biology; Gene; Genome; Hypha; Microbiology; Botany","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008304843,0.0005096273,0.0005439447,0.0001653934,0.0003585285,0.0000751436,0.0007984222,0.0003412048,0.0001303514],"category_scores_gemma":[0.0001881616,0.0004380801,0.0002292158,0.0005907979,0.0002077301,0.000004908551,0.001857315,0.0005668538,0.00003122062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009377101,"about_ca_system_score_gemma":0.0003239862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004540513,"about_ca_topic_score_gemma":0.00001065759,"domain_scores_codex":[0.9968827,0.000238324,0.0006754294,0.001362387,0.0003659232,0.0004751831],"domain_scores_gemma":[0.9968573,0.0000196506,0.0004729029,0.002114225,0.0004156012,0.000120346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008982344,0.000136722,0.006051035,0.0001647989,0.0005227333,0.000009931252,0.00002984459,0.000450247,0.9832948,0.0004509882,0.008791899,0.000007148086],"study_design_scores_gemma":[0.0005581345,0.000403295,0.2468652,0.00009577391,0.0002719394,1.3989e-7,0.00007152031,0.00002481589,0.3298387,0.000006381457,0.4209614,0.0009027498],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889536,0.006190291,0.0001673917,0.0011184,0.0013965,0.001361523,0.0006486111,0.00009217691,0.00007149945],"genre_scores_gemma":[0.996737,0.0009168104,0.0008010219,0.0002836497,0.0005260751,0.000405315,0.00000687556,0.0001164521,0.0002067928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6534561,"threshold_uncertainty_score":0.9998071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.017567698288192,"score_gpt":0.230066655215049,"score_spread":0.212498956926857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}